Kolomytkin O V, Ermishkin L N
Biofizika. 1976 Nov;21(6):1008-12.
It is shown that there are spasmodic changes of electroconductivity in bimolecular membranes in the presence of alpha-chimotripsin and denatured ovalbumin or glycyl-d,L-beta-phenylalanine. These conductivity changes are not due to the interaction ob proteolysis products with lipid bilayer but result from the interaction of alpha-chimo trypsin with the substrate or competing inhibitor. Probability of the state with a specific conductivity depends on the membrane voltage. A modified membrane has a low ionic selectivity.
结果表明，在存在α-胰凝乳蛋白酶和变性卵清蛋白或甘氨酰-d，L-β-苯丙氨酸的情况下，双分子膜的电导率会发生痉挛性变化。这些电导率变化并非由于蛋白水解产物与脂质双层的相互作用，而是由α-胰凝乳蛋白酶与底物或竞争性抑制剂的相互作用导致的。具有特定电导率状态的概率取决于膜电压。修饰后的膜具有较低的离子选择性。
