Gegenava G P, Chistiakov V V
Biofizika. 1979 Jan-Feb;24(1):67-71.
It has been shown that morphine, codeine, dionine and nalorphine do not change significantly the electroconductivity of bilayer lipid membranes (BLM) in the presence of potassium ions in the medium. Changes in BLM phospholipid composition, KC1 and opiate concentration in the medium, as well as the ratio between ionized and unionized forms of the narcotics do not affect the conductivity of lipid bilayers. A conclusion is made that morphine derivatives do not produce immediate effect on membrane potassium permeability.
已表明，在介质中存在钾离子的情况下，吗啡、可待因、地奥宁和烯丙吗啡不会显著改变双层脂质膜（BLM）的电导率。介质中BLM磷脂组成、KC1和阿片类药物浓度的变化，以及麻醉剂离子化和非离子化形式之间的比例，均不影响脂质双层的电导率。得出的结论是，吗啡衍生物不会对膜钾通透性产生即时影响。
