Zelkovamycin，一种来自链霉菌属K96 - 0670的新型环肽抗生素。I. 生产、分离及生物学特性
Zelkovamycin, a new cyclic peptide antibiotic from Streptomyces sp. K96-0670. I. Production, isolation and biological properties.
作者信息
Zhang H, Tomoda H, Tabata N, Oohori M, Shinose M, Takahashi Y, Omura S
机构信息
Research Center for Biological Function, The Kitasato Institute and Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1999 Jan;52(1):29-33. doi: 10.7164/antibiotics.52.29.
PMID:10092194
Abstract
A new antibiotic termed zelkovamycin was isolated from the fermentation broth of Streptomyces sp. K96-0670 by solvent extraction, ODS column chromatography and preparative HPLC. Zelkovamycin showed antibacterial activity against Xanthomonas oryzae, Acholeplasma laidlawii, Pyricularia oryzae and Staphylococcus aureus.
摘要
一种名为 Zelkovamycin 的新型抗生素通过溶剂萃取、ODS 柱色谱法和制备型高效液相色谱法从链霉菌属菌株 K96 - 0670 的发酵液中分离得到。Zelkovamycin 对水稻黄单胞菌、莱氏无胆甾原体、稻瘟病菌和金黄色葡萄球菌具有抗菌活性。
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