Claes L E, Heigele C A
Department Unfallchirurgische Forschung und Biomechanik, University of Ulm, Germany.
J Biomech. 1999 Mar;32(3):255-66. doi: 10.1016/s0021-9290(98)00153-5.
A new quantitative tissue differentiation theory which relates the local tissue formation in a fracture gap to the local stress and strain is presented. Our hypothesis proposes that the amounts of strain and hydrostatic pressure along existing calcified surfaces in the fracture callus determine the differentiation of the callus tissue. The study compares the local strains and stresses in the callus as calculated from a finite element model with histological findings from an animal fracture model. The hypothesis predicts intramembranous bone formation for strains smaller approximately +/- 5% and hydrostatic pressures smaller than +/- 0.15 MPa. Endochondral ossification is associated with compressive pressures larger than about -0.15 MPa and strains smaller than +/- 15%. All other conditions seemed to lead to connective tissue or fibrous cartilage. The hypothesis enables a better understanding of the complex tissue differentiation seen in histological images and the mechanical conditions for healing delayed healing or nonunions.
提出了一种新的定量组织分化理论，该理论将骨折间隙中的局部组织形成与局部应力和应变联系起来。我们的假设提出，骨折痂中沿现有钙化表面的应变和静水压力的量决定了痂组织的分化。该研究将从有限元模型计算出的痂中的局部应变和应力与动物骨折模型的组织学结果进行了比较。该假设预测，应变小于约±5%且静水压力小于±0.15MPa时会发生膜内骨形成。软骨内成骨与大于约-0.15MPa的压缩压力和小于±15%的应变有关。所有其他情况似乎都会导致结缔组织或纤维软骨。该假设有助于更好地理解组织学图像中看到的复杂组织分化以及愈合延迟愈合或骨不连的力学条件。
