Rowe F J, Sarkies N J
Department of Orthoptics, University of Liverpool, UK.
Int J Obes Relat Metab Disord. 1999 Jan;23(1):54-9. doi: 10.1038/sj.ijo.0800758.
To evaluate the association between obesity and idiopathic intracranial hypertension (IIH) and establish whether there is a relationship with visual outcome. To calculate the prevalence and degree of obesity in a group of patients with IIH.
34 patients (31 female and 3 male) were recruited between 1993 - 1997 with a diagnosis of IIH. Assessment included visual acuity, visual field assessment (Humphrey automated and Goldmann manual perimetry), fundus assessment and measurement of body mass index (BMI). Obesity was defined as a BMI of 30 kg/m2.
70.5% of patients were obese. The relative risk for obesity and IIH was significant at 8 (95%CI: 2,29). This increased to 17 (95%CI: 5,62) for obese females aged 16 to 24 years and 10 (95%CI: 3,35.5) for obese females aged 25 to 34 years. Morbid obesity (BMI > 40) was significantly associated with poor visual outcome. Serial obesity measures showed generally little change in weight over time and there was no correlation between weight change and visual improvement.
This study has documented a relationship between obesity and IIH. A high degree of obesity was associated with a poor visual function and identified as a risk factor for poor outcome. Obesity may be an aetiological factor in this condition although it is unlikely to be the sole cause but more probably a precipitating factor. Weight loss is recommended although failure to lose weight is common. Any weight reduction programme must therefore be actively encouraged and monitored.
评估肥胖与特发性颅内高压（IIH）之间的关联，并确定其与视力预后是否存在关系。计算一组IIH患者的肥胖患病率及肥胖程度。
1993年至1997年间招募了34例诊断为IIH的患者（31例女性，3例男性）。评估内容包括视力、视野评估（Humphrey自动视野计和Goldmann手动视野计）、眼底评估以及体重指数（BMI）测量。肥胖定义为BMI≥30kg/m²。
70.5%的患者肥胖。肥胖与IIH的相对风险显著，为8（95%置信区间：2,29）。16至24岁肥胖女性的相对风险增至17（95%置信区间：5,62），25至34岁肥胖女性的相对风险为10（95%置信区间：3,35.5）。病态肥胖（BMI>40）与视力预后不良显著相关。系列肥胖测量显示，体重随时间总体变化不大，体重变化与视力改善之间无相关性。
本研究证实了肥胖与IIH之间的关系。高度肥胖与视力功能不良相关，并被确定为预后不良的危险因素。肥胖可能是该病的一个病因，尽管不太可能是唯一原因，但很可能是一个促发因素。建议减肥，尽管减肥失败很常见。因此，必须积极鼓励并监测任何减肥计划。
