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本文引用的文献

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Upregulation of a histone-like protein in dormant Mycobacterium smegmatis.耻垢分枝杆菌休眠状态下一种组蛋白样蛋白的上调
Mol Gen Genet. 1998 Dec;260(5):475-9. doi: 10.1007/s004380050919.
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Action of metronidazole in combination with isoniazid & rifampicin on persisting organisms in experimental murine tuberculosis.
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Increased alanine dehydrogenase activity during dormancy in Mycobacterium smegmatis.耻垢分枝杆菌休眠期间丙氨酸脱氢酶活性增加。
FEMS Microbiol Lett. 1998 Oct 1;167(1):7-11. doi: 10.1111/j.1574-6968.1998.tb13200.x.
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The 16-kDa alpha-crystallin-like protein of Mycobacterium bovis BCG is produced under conditions of oxygen deficiency and is associated with ribosomes.牛分枝杆菌卡介苗的16 kDaα-晶体样蛋白在缺氧条件下产生，并与核糖体相关。
Res Microbiol. 1998 Apr;149(4):255-64. doi: 10.1016/s0923-2508(98)80301-x.
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Metronidazole has no antibacterial effect in Cornell model murine tuberculosis.
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The 16-kDa alpha-crystallin (Acr) protein of Mycobacterium tuberculosis is required for growth in macrophages.结核分枝杆菌的16千道尔顿α-晶体蛋白（Acr）是巨噬细胞生长所必需的。
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Oxygen depletion induced dormancy in Mycobacterium smegmatis.
FEMS Microbiol Lett. 1998 Jun 15;163(2):159-64. doi: 10.1111/j.1574-6968.1998.tb13040.x.
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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.从全基因组序列解读结核分枝杆菌的生物学特性。
Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
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Mechanisms of latency in Mycobacterium tuberculosis.结核分枝杆菌的潜伏机制。
Trends Microbiol. 1998 Mar;6(3):107-12. doi: 10.1016/s0966-842x(98)01216-5.
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Mycobacterial stationary phase induced by low oxygen tension: cell wall thickening and localization of the 16-kilodalton alpha-crystallin homolog.低氧张力诱导的分枝杆菌稳定期：细胞壁增厚及16千道尔顿α-晶状体蛋白同源物的定位
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牛分枝杆菌卡介苗中氧耗竭诱导的休眠

Oxygen depletion-induced dormancy in Mycobacterium bovis BCG.

作者信息

Lim A, Eleuterio M, Hutter B, Murugasu-Oei B, Dick T

机构信息

Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore.

出版信息

J Bacteriol. 1999 Apr;181(7):2252-6. doi: 10.1128/JB.181.7.2252-2256.1999.

DOI:10.1128/JB.181.7.2252-2256.1999
PMID:10094705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC93640/
Abstract

Gradual depletion of oxygen causes the shift-down of aerobic growing Mycobacterium bovis BCG to an anaerobic synchronized state of nonreplicating persistence. The persistent culture shows induction of glycine dehydrogenase and alpha-crystallin-like protein and is sensitive to metronidazole.

摘要

氧气的逐渐消耗会导致需氧生长的牛分枝杆菌卡介苗转变为非复制性持续存在的厌氧同步状态。处于持续状态的培养物表现出甘氨酸脱氢酶和α-晶状体样蛋白的诱导，并且对甲硝唑敏感。