牛分枝杆菌卡介苗中氧耗竭诱导的休眠
Oxygen depletion-induced dormancy in Mycobacterium bovis BCG.
作者信息
Lim A, Eleuterio M, Hutter B, Murugasu-Oei B, Dick T
机构信息
Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore.
出版信息
J Bacteriol. 1999 Apr;181(7):2252-6. doi: 10.1128/JB.181.7.2252-2256.1999.
Abstract
Gradual depletion of oxygen causes the shift-down of aerobic growing Mycobacterium bovis BCG to an anaerobic synchronized state of nonreplicating persistence. The persistent culture shows induction of glycine dehydrogenase and alpha-crystallin-like protein and is sensitive to metronidazole.
摘要
氧气的逐渐消耗会导致需氧生长的牛分枝杆菌卡介苗转变为非复制性持续存在的厌氧同步状态。处于持续状态的培养物表现出甘氨酸脱氢酶和α-晶状体样蛋白的诱导，并且对甲硝唑敏感。
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