Veldman J E, Molenaar I, Keuning F J
Virchows Arch B Cell Pathol. 1978 Oct 16;28(3):217-28. doi: 10.1007/BF02889071.
Three times sublethal total body X-irradiation with thymus shielding--at 14 days' intervals--established an 'isolated T-cell system'. Cellular immunity reactions in draining lymph nodes of rabbits have been analyzed at the ultrastructural level after challenge with horse spleen ferritin, the chemical sensitizer, 2-phenyl-4-ethoxymethylene-5-oxazolone and after skin allografting. A basic pattern of interdigitating cells (IDC) is described as a specific constituent of the thymus-dependent areas of peripheral lymphoid tissue. Their ultrastructural features and presumable functional relationship to the afferent loop of cellular immunity reactions are presented. The differentiation pathway of two T-cell lines is shown and discussed in relation to cellular and thymus-dependent humoral immunity reactions.
采用胸腺屏蔽，以14天的间隔进行三次亚致死性全身X射线照射，建立了一个“孤立T细胞系统”。在用化学致敏剂马脾铁蛋白、2-苯基-4-乙氧基亚甲基-5-恶唑酮激发后以及皮肤同种异体移植后，在超微结构水平上分析了兔引流淋巴结中的细胞免疫反应。描述了树突状细胞（IDC）的基本模式，作为外周淋巴组织中胸腺依赖区的一种特定成分。展示了它们的超微结构特征以及与细胞免疫反应传入环可能的功能关系。展示并讨论了两条T细胞系的分化途径与细胞免疫和胸腺依赖的体液免疫反应的关系。
