Endresen L P, Høye J S
Institutt for fysikk, Norges Teknisk Naturvitenskapelige Universitat, N-7034 Trondheim, Norway.
Biophys J. 1999 Apr;76(4):1918-21. doi: 10.1016/S0006-3495(99)77350-9.
We introduce a Markov model for the gating of membrane channels. The model features a possible solution to the so-called gating current paradox, namely that the bell-shaped curve that describes the voltage dependence of the kinetics is broader than expected from, and shifted relative to, the sigmoidal curve that describes the voltage dependence of the activation. The model also predicts some temperature dependence of this shift, but presence of the latter has not been tested experimentally so far.
我们引入了一种用于膜通道门控的马尔可夫模型。该模型为所谓的门控电流悖论提供了一种可能的解决方案，即描述动力学电压依赖性的钟形曲线比描述激活电压依赖性的S形曲线更宽且相对其发生了偏移。该模型还预测了这种偏移存在一定的温度依赖性，但到目前为止，后者的存在尚未经过实验验证。
