离子通道门控电流的波动。非平稳散粒噪声分析。
Fluctuations in ion channel gating currents. Analysis of nonstationary shot noise.
作者信息
Crouzy S C, Sigworth F J
机构信息
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510.
出版信息
Biophys J. 1993 Jan;64(1):68-76. doi: 10.1016/S0006-3495(93)81341-9.
Abstract
Conti and Stühmer (1989. Eur. Biophys. J. 17:53-59) have measured the nonstationary shot noise in the gating current of a population of sodium channels. Here we present expressions for the autocovariance and variance of such noise from general Markov models of channel kinetics, based on the theoretical work of E. Frehland. We compare the predictions of the independent, two-state gating model used by Conti and Stühmer with a six-state model of sodium channel activation based on the work of Armstrong and Gilly (1979. J. Gen. Physiol. 74:691-711). We find that Conti and Stühmer's experiment would not be able to distinguish between these schemes. We describe experimental conditions under which better model discrimination would be possible.
摘要
康蒂和施图默（1989年，《欧洲生物物理杂志》17卷：53 - 59页）测量了一群钠通道门控电流中的非平稳散粒噪声。在此，基于E. 弗雷兰德的理论工作，我们给出了通道动力学一般马尔可夫模型中此类噪声的自协方差和方差的表达式。我们将康蒂和施图默所使用的独立双态门控模型的预测结果与基于阿姆斯特朗和吉利（1979年，《普通生理学杂志》74卷：691 - 711页）的工作得出的钠通道激活六态模型进行了比较。我们发现，康蒂和施图默的实验无法区分这些机制。我们描述了能够实现更好的模型辨别的实验条件。
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