位于8号染色体p22区域的FEZ1基因编码一种亮氨酸拉链蛋白，其表达在多种人类肿瘤中发生改变。
The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors.
作者信息
Ishii H, Baffa R, Numata S I, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce C M
机构信息
Kimmel Cancer Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
出版信息
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3928-33. doi: 10.1073/pnas.96.7.3928.
Abstract
Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis. cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. RNA blot analysis revealed that FEZ1 gene expression was undetectable in more than 60% of epithelial tumors. Mutations were found in primary esophageal cancers and in a prostate cancer cell line. Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors.
摘要
人类8号染色体短臂（8p）的改变在许多肿瘤中频繁发生。我们通过等位基因分型分析在8p22区域鉴定出一个1.5兆碱基（Mb）的常见等位基因缺失区域。通过cDNA筛选分离出了几个基因，包括FEZ1。预测的Fez1蛋白含有一个亮氨酸拉链区域，与环磷酸腺苷（cAMP）反应性激活转录因子5的DNA结合结构域相似。RNA印迹分析显示，超过60%的上皮肿瘤中检测不到FEZ1基因表达。在原发性食管癌和一种前列腺癌细胞系中发现了突变。对几种表达FEZ1的肿瘤进行转录本分析，发现了截短的mRNA，包括移码突变。FEZ1基因的改变和失活可能在多种人类肿瘤中起作用。
相似文献
1
The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors.位于8号染色体p22区域的FEZ1基因编码一种亮氨酸拉链蛋白，其表达在多种人类肿瘤中发生改变。
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3928-33. doi: 10.1073/pnas.96.7.3928.
2
Fez1/lzts1 alterations in gastric carcinoma.胃癌中Fez1/lzts1的改变
Clin Cancer Res. 2001 Jun;7(6):1546-52.
3
LAPSER1: a novel candidate tumor suppressor gene from 10q24.3.LAPSER1：一个来自10q24.3的新型候选肿瘤抑制基因。
Oncogene. 2001 Oct 11;20(46):6707-17. doi: 10.1038/sj.onc.1204866.
4
Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity in oral squamous cell carcinomas.FEZ1/LZTS1基因下调且在口腔鳞状细胞癌中频繁发生杂合性缺失。
Int J Oncol. 2003 Aug;23(2):297-302.
5
Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures.FEZ1/LZTS1基因在肺癌及其细胞培养物中的差异表达。
Clin Cancer Res. 2002 Jul;8(7):2292-7.
6
FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.位于8p22的FEZ1/LZTS1基因可抑制癌细胞生长并调节有丝分裂。
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10374-9. doi: 10.1073/pnas.181222898. Epub 2001 Aug 14.
7
Mutation analysis of the 8p candidate tumour suppressor genes DBC2 (RHOBTB2) and LZTS1 in bladder cancer.膀胱癌中8p候选抑癌基因DBC2（RHOBTB2）和LZTS1的突变分析。
Cancer Lett. 2005 Jul 8;225(1):121-30. doi: 10.1016/j.canlet.2004.10.047. Epub 2004 Dec 10.
8
Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer.肺癌中FEZ1/LZTS1表达降低与预后预测
Cancer Res. 2005 Feb 15;65(4):1207-12. doi: 10.1158/0008-5472.CAN-04-3461.
9
FEZ1/LZTS1 is down-regulated in high-grade bladder cancer, and its restoration suppresses tumorigenicity in transitional cell carcinoma cells.FEZ1/LZTS1在高级别膀胱癌中表达下调，其恢复可抑制移行细胞癌细胞的致瘤性。
Am J Pathol. 2002 Apr;160(4):1345-52. doi: 10.1016/S0002-9440(10)62561-8.
10
Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein.参与轴突生长的秀丽隐杆线虫UNC-76蛋白的哺乳动物同源物是一种蛋白激酶Cζ相互作用蛋白。
J Cell Biol. 1999 Feb 8;144(3):403-11. doi: 10.1083/jcb.144.3.403.
引用本文的文献
1
Tumor Suppressor LncRNA on Chromosome 8p12 (TSLNC8): A Concise Review in Human Malignancies.8号染色体p12上的肿瘤抑制长链非编码RNA（TSLNC8）：人类恶性肿瘤的简要综述
J Cancer. 2023 Sep 11;14(15):2867-2877. doi: 10.7150/jca.87801. eCollection 2023.
2
Protein Phosphatase 1 Regulatory Subunit 3: A Prognostic Biomarker in Stomach Adenocarcinoma.蛋白磷酸酶1调节亚基3：胃腺癌中的一种预后生物标志物。
Int J Gen Med. 2022 Feb 4;15:1131-1146. doi: 10.2147/IJGM.S345978. eCollection 2022.
3
Long non-coding RNA Lnc-LALC facilitates colorectal cancer liver metastasis via epigenetically silencing LZTS1.长链非编码 RNA Lnc-LALC 通过表观遗传沉默 LZTS1 促进结直肠癌肝转移。
Cell Death Dis. 2021 Feb 26;12(2):224. doi: 10.1038/s41419-021-03461-w.
4
Comprehensive study of altered proteomic landscape in proximal renal tubular epithelial cells in response to calcium oxalate monohydrate crystals.全面研究草酸钙一水合物晶体对近端肾小管上皮细胞蛋白质组景观的改变。
BMC Urol. 2020 Aug 31;20(1):136. doi: 10.1186/s12894-020-00709-z.
5
Whole genome sequencing of familial isolated oesophagus atresia uncover shared structural variants.家族性孤立性食管闭锁的全基因组测序揭示了共享的结构变异。
BMC Med Genomics. 2020 Jun 26;13(1):85. doi: 10.1186/s12920-020-00737-6.
6
Screening of key genes associated with R‑CHOP immunochemotherapy and construction of a prognostic risk model in diffuse large B‑cell lymphoma.筛选与 R-CHOP 免疫化疗相关的关键基因，并构建弥漫性大 B 细胞淋巴瘤的预后风险模型。
Mol Med Rep. 2019 Oct;20(4):3679-3690. doi: 10.3892/mmr.2019.10627. Epub 2019 Aug 29.
7
Fasciculation and elongation zeta proteins 1 and 2: From structural flexibility to functional diversity.成束和延伸ζ蛋白1和2：从结构灵活性到功能多样性
World J Biol Chem. 2019 Feb 21;10(2):28-43. doi: 10.4331/wjbc.v10.i2.28.
8
Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.描绘前列腺和卵巢上皮细胞中的HMGB1和HMGB2相互作用组及其与癌症的关系。
Oncotarget. 2018 Apr 10;9(27):19050-19064. doi: 10.18632/oncotarget.24887.
9
PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity.PSD-Zip70缺乏通过Rap2活性失调导致与谷氨酸能突触成熟缺陷相关的前额叶功能减退。
J Neurosci. 2015 Oct 21;35(42):14327-40. doi: 10.1523/JNEUROSCI.2349-15.2015.
10
MicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell Carcinoma.微小RNA-135b在皮肤鳞状细胞癌中调控亮氨酸拉链肿瘤抑制因子1
PLoS One. 2015 May 4;10(5):e0125412. doi: 10.1371/journal.pone.0125412. eCollection 2015.
本文引用的文献
1
Localization of chromosome 8p regions involved in early tumorigenesis of oral and laryngeal squamous carcinoma.参与口腔和喉鳞状细胞癌早期肿瘤发生的8号染色体短臂区域的定位
Oncogene. 1998 Jun 11;16(23):2983-7. doi: 10.1038/sj.onc.1201808.
2
Allelic loss of chromosomal arm 8p in breast cancer progression.乳腺癌进展过程中染色体8p臂的等位基因缺失。
Am J Pathol. 1998 Mar;152(3):815-9.
3
Prognostic significance of allelic imbalance of chromosome arms 7q, 8p, 16q, and 18q in stage T3N0M0 prostate cancer.7号染色体长臂、8号染色体短臂、16号染色体长臂和18号染色体长臂等位基因失衡在T3N0M0期前列腺癌中的预后意义
Genes Chromosomes Cancer. 1998 Feb;21(2):131-43.
4
Deletion mapping defines three discrete areas of allelic imbalance on chromosome arm 8p in oral and oropharyngeal squamous cell carcinomas.缺失图谱确定了口腔和口咽鳞状细胞癌8号染色体短臂上等位基因不平衡的三个离散区域。
Genes Chromosomes Cancer. 1997 Dec;20(4):347-53. doi: 10.1002/(sici)1098-2264(199712)20:4<347::aid-gcc5>3.0.co;2-1.
5
Genome-wide search for loss of heterozygosity shows extensive genetic diversity of human breast carcinomas.全基因组杂合性缺失搜索显示人类乳腺癌具有广泛的遗传多样性。
Cancer Res. 1997 Dec 15;57(24):5469-74.
6
Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion.FRA3B常见脆性区域的序列：对FHIT基因缺失机制的启示
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14584-9. doi: 10.1073/pnas.94.26.14584.
7
N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions.结直肠癌中的N-乙酰转移酶2基因型以及8号染色体短臂缺失的癌症中的选择性基因保留
Gut. 1997 Aug;41(2):229-34. doi: 10.1136/gut.41.2.229.
8
Mapping AAC1, AAC2 and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumours.绘制芳胺N - 乙酰基转移酶（致癌物代谢酶）的基因AAC1、AAC2和AACP在人类8号染色体p22区域的图谱，该区域在肿瘤中经常缺失。
Cytogenet Cell Genet. 1997;77(3-4):290-5. doi: 10.1159/000134601.
9
Chromosome 8p deletions are associated with invasive tumor growth in urinary bladder cancer.8号染色体短臂缺失与膀胱癌的侵袭性肿瘤生长相关。
Am J Pathol. 1997 Sep;151(3):753-9.
Zotero 插件