病毒的毒力进化遵循一种权衡。
Virulence evolution in a virus obeys a trade-off.
作者信息
Messenger S L, Molineux I J, Bull J J
机构信息
Department of Zoology, University of Texas, Austin 78712, USA.
出版信息
Proc Biol Sci. 1999 Feb 22;266(1417):397-404. doi: 10.1098/rspb.1999.0651.
The evolution of virulence was studied in a virus subjected to alternating episodes of vertical and horizontal transmission. Bacteriophage f1 was used as the parasite because it establishes a debilitating but non-fatal infection that can be transmitted vertically (from a host to its progeny) as well as horizontally (infection of new hosts). Horizontal transmission was required of all phage at specific intervals, but was prevented otherwise. Each episode of horizontal transmission was followed by an interval of obligate vertical transmission, followed by an interval of obligate horizontal transmission etc. The duration of vertical transmission was eight times longer per episode in one treatment than in the other, thus varying the relative intensity of selection against virulence while maintaining selection for some level of virus production. Viral lines with the higher enforced rate of infectious transmission evolved higher virulence and higher rates of virus production. These results support the trade-off model for the evolution of virulence.
对一种经历垂直和水平传播交替阶段的病毒的毒力进化进行了研究。噬菌体f1被用作寄生生物，因为它会引发一种使人衰弱但不致命的感染，这种感染既可以垂直传播（从宿主传给其后代），也可以水平传播（感染新宿主）。所有噬菌体在特定间隔需要进行水平传播，否则则会被阻止。每次水平传播阶段之后是一段专性垂直传播间隔，接着是一段专性水平传播间隔等等。在一种处理中，每次垂直传播的持续时间比另一种处理长八倍，从而在保持对一定水平病毒产生进行选择的同时，改变了针对毒力的选择相对强度。具有更高强制感染传播率的病毒株进化出了更高的毒力和更高的病毒产生率。这些结果支持了毒力进化的权衡模型。
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