Hashimoto K, Higuchi M, Makino B, Sakakibara I, Kubo M, Komatsu Y, Maruno M, Okada M
Central Research Laboratories, Tsumura and Company, Ibaraki, Japan.
J Ethnopharmacol. 1999 Feb;64(2):185-9. doi: 10.1016/s0378-8741(98)00123-8.
The amounts of aristolochic acid I and II in four groups of medicinal plants from the Aristolochiaceae and some related plants were determined by high-pressure liquid chromatography, for Aristolochia was reported to produce interstitial nephritis caused by aristolochic acids during chronic use for the treatment of rheumatism, diuretic and analgesic. They were detected in all the plants that originated from the genus Aristolochia (Aristolochiaceae) and in some of the plants from the genus Asarum (Aristolochiaceae). The present results suggest that these medicinal plants should be prohibited to use for remedy due to the harmful effects attributed to aristolochic acids.
采用高压液相色谱法测定了马兜铃科四组药用植物及一些相关植物中马兜铃酸I和II的含量，因为据报道，马兜铃属植物在长期用于治疗风湿、利尿和止痛时会产生由马兜铃酸引起的间质性肾炎。在所有源自马兜铃属（马兜铃科）的植物以及一些细辛属（马兜铃科）植物中均检测到了马兜铃酸。目前的结果表明，由于马兜铃酸具有有害作用，这些药用植物应禁止用于治疗。
