McCredie M, Williams S, Coates M
Cancer Epidemiology Research Unit, New South Wales Cancer Council, Australia.
Br J Cancer. 1999 Mar;79(7-8):1277-82. doi: 10.1038/sj.bjc.6690205.
Routinely collected data for New South Wales were used to analyse cancer mortality in migrants born in East or Southeast Asia according to duration of residence in Australia. A case-control approach compared deaths from cancer at particular sites with deaths from all other cancers, adjusting for age, sex and calendar period. Compared with the Australian-born, these Asian migrants had a 30-fold higher risk of dying from nasopharyngeal cancer in the first 2 decades of residence, falling to ninefold after 30 years, and for deaths from liver cancer, a 12-fold risk in the first 2 decades, falling to threefold after 30 years. The initial lower risk from colorectal, breast or prostate cancers later converged towards the Australian-born level, the change being apparent in the third decade after migration. The relative risk of dying from lung cancer among these Asian migrants was above unity for each category of duration of stay for women, but at or below unity for men, with no trend in risk over time. An environmental or lifestyle influence for nasopharyngeal and liver cancers is suggested as well as for cancers of colon/rectum, breast and prostate.
新南威尔士州常规收集的数据被用于分析出生于东亚或东南亚的移民在澳大利亚的居住时长与癌症死亡率之间的关系。采用病例对照方法，将特定部位癌症死亡病例与所有其他癌症死亡病例进行比较，并对年龄、性别和日历时间段进行了调整。与澳大利亚本土出生的人相比，这些亚洲移民在居住的头20年里死于鼻咽癌的风险高出30倍，30年后降至9倍；死于肝癌的风险在头20年里为12倍，30年后降至3倍。结直肠癌、乳腺癌或前列腺癌最初较低的风险后来逐渐趋近于澳大利亚本土出生者的水平，这种变化在移民后的第三个十年中较为明显。这些亚洲移民中，女性在各个停留时长类别中死于肺癌的相对风险均高于1，但男性则等于或低于1，且风险随时间没有变化趋势。这表明鼻咽癌、肝癌以及结肠/直肠癌、乳腺癌和前列腺癌受到环境或生活方式的影响。
