Arishima K, Morikawa Y, Hashimoto Y, Eguchi Y
Endocrinol Jpn. 1976 Oct;23(5):429-30. doi: 10.1507/endocrj1954.23.429.
Two hr after birth, newborn rats were given a subcutaneous injection of 0.01 mg estradiol benzoate dissolved in 0.05 ml sesame oil. Other siblings were given sesame oil alone. Autopsy was performed on days 1, 2 and 3 after birth. Gravimetric and histologic examinations of the adrenals from these animals and from normal littermate controls were made together with the determination of plasma corticosterone concentrations. In all the three groups of rats, estrogen-treated, oil-treated and non-treated, the weight of the adrenal glands declined with a concomitant decrease in the plasma corticosterone concentrations. The results indicate that estradiol benzoate, when given after birth, does not prevent the neonatal adrenal from shrinking.
出生后两小时，给新生大鼠皮下注射溶于0.05毫升芝麻油的0.01毫克苯甲酸雌二醇。其他同窝出生的大鼠仅注射芝麻油。在出生后的第1、2和3天进行尸检。对这些动物以及正常同窝对照动物的肾上腺进行重量测定和组织学检查，并测定血浆皮质酮浓度。在所有三组大鼠中，即雌激素处理组、油处理组和未处理组，肾上腺重量均下降，同时血浆皮质酮浓度也降低。结果表明，出生后给予苯甲酸雌二醇并不能阻止新生大鼠肾上腺萎缩。
