Gak J C, Graillot C, Turhaut R
Eur J Toxicol Environ Hyg. 1976 Sep-Oct;9(5):303-12.
Rats and hamsters were fed ETU at levels of 0, 5, 17, 60, 200 mg/kg in the diet. Body weights, food consumption, seric enzyme activities (GPT, alkaline phosphatase), hepatic enzyme activities (GPT, alkaline phosphatase G6PDH), cholesterolemia, thyroid weight and others organs, histology were the criteria studied. ETU was found causing hypercholesterolemia for the 2 species at 5 mg/kg dietary levels. Thyroid impairement is predominant in rat and hepatic impairment is predominant in hamster. ETU was found to be not carcinogenic for hamsters even at 200 mg/kg level and carcinogenic for rats at 60 mg/kg level for males and 200 mg/kg level for females.
给大鼠和仓鼠喂食饮食中ETU含量分别为0、5、17、60、200毫克/千克的食物。研究标准包括体重、食物摄入量、血清酶活性（谷丙转氨酶、碱性磷酸酶）、肝酶活性（谷丙转氨酶、碱性磷酸酶、葡萄糖-6-磷酸脱氢酶）、胆固醇血症、甲状腺重量以及其他器官和组织学。发现饮食中ETU含量为5毫克/千克时，这两个物种均出现高胆固醇血症。大鼠主要出现甲状腺损伤，仓鼠主要出现肝脏损伤。发现即使饮食中ETU含量为200毫克/千克，对仓鼠也无致癌性；对雄性大鼠，饮食中ETU含量为60毫克/千克时有致癌性，对雌性大鼠，饮食中ETU含量为200毫克/千克时有致癌性。
