Houeto P, Bindoula G, Hoffman J R
Laboratoire de Toxicologie, Hopital Fernand Widal, Paris, France.
Environ Health Perspect. 1995 Jun;103(6):568-73. doi: 10.1289/ehp.95103568.
Humans are exposed to ethylenebisdithiocarbamates (EBDCs) from environmental sources. Exposure to EBDCs is chronic for workers in a variety of industries, where EBDCs are used for their properties as slimicides, vulcanization accelerators, antioxidants, and scavengers in waste-water treatment. EBDCs, and particularly the EBDC metabolite ethylenethiourea, have clearly defined, important toxic effects in various animal species, and there is reason to suspect they are carcinogenic in humans. In the absence of definitive information regarding human risk, further studies need to be done. In the interim, regular surveillance of workers with high levels of exposure to EBDCs, with specific attention to markers of thyroid and hepatic pathology, should be considered.
人类通过环境接触乙撑双二硫代氨基甲酸盐（EBDCs）。在各种行业中，EBDCs作为杀粘菌剂、硫化促进剂、抗氧化剂和废水处理中的清除剂使用，工人长期接触EBDCs。EBDCs，尤其是EBDC代谢物乙撑硫脲，在各种动物物种中具有明确的重要毒性作用，并且有理由怀疑它们对人类具有致癌性。在缺乏关于人类风险的确切信息的情况下，需要进一步开展研究。在此期间，应考虑对高暴露水平的EBDC工人进行定期监测，特别关注甲状腺和肝脏病理学指标。
