Austin G E, Moyer G H
Res Commun Chem Pathol Pharmacol. 1979 Mar;23(3):639-42.
The ability of ethylene thiourea (ETU) to inhibit RNA synthesis in rat liver was investigated. This compound, a possibly carcinogenic metabolite to the ethylene-bis-dithiocarbamate fungicides, was administered to rats by intraperitoneal injection, by nasogastric tube and in the diet, and rates of RNA synthesis were determined. By contrast with the carcinogens thioacetamide and acetylaminofluorene, high doses of ETU administered by any of these routes failed to inhibit the synthesis of nuclear or cytoplasmic RNA. In this respect ETU appears to differ from most hepatocarcinogens in its effect on cellular metabolism.
研究了乙烯硫脲（ETU）抑制大鼠肝脏中RNA合成的能力。该化合物是乙烯双二硫代氨基甲酸酯类杀菌剂的一种可能致癌的代谢产物，通过腹腔注射、鼻胃管给药和添加到饮食中给予大鼠，并测定RNA合成速率。与致癌物硫代乙酰胺和乙酰氨基芴相比，通过这些途径中的任何一种给予高剂量的ETU均未能抑制核RNA或细胞质RNA的合成。在这方面，ETU在对细胞代谢的影响上似乎与大多数肝癌致癌物不同。
