Lichtenstein P, Källén B, Köster M
Institute for Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Twin Res. 1998 Dec;1(4):212-5. doi: 10.1375/136905298320566186.
Previous research has provided evidence for a genetic effect in monozygotic twinning, indicated by an increased risk for monozygotic women to have monozygotic offspring. However, since the biological mechanism for this trait is unknown, it is not clear if there exists a paternal inheritance. In this study we investigated twin pregnancies in offspring born in 1941-1996 to male twins in the Swedish Twin Registry and population controls born in 1926-1980. In total 4,225,331 offspring, of which 89,286 were twins, were studied. There was neither an increase in the probability for monozygotic men to have like-sexed twin offspring risk ratio (RR = 0.95; 95% CI = 0.77-1.13) nor an increase in the estimated number of monozygotic twin births. Thus, there is no evidence for a paternal effect on monozygotic twinning, suggesting that the gene(s) increasing the liability for division of the embryo are expressed in the mother and not in the fertilised egg.
先前的研究为同卵双胞胎的遗传效应提供了证据，表现为同卵双胞胎女性生育同卵后代的风险增加。然而，由于该性状的生物学机制尚不清楚，所以尚不清楚是否存在父系遗传。在本研究中，我们调查了瑞典双胞胎登记处中1941年至1996年出生的男性双胞胎的后代中的双胎妊娠情况，以及1926年至1980年出生的人群对照。总共研究了4,225,331名后代，其中89,286名是双胞胎。同卵双胞胎男性生育同性双胞胎后代的风险比（RR = 0.95；95% CI = 0.77 - 1.13）没有增加，同卵双胞胎出生的估计数量也没有增加。因此，没有证据表明父系对同卵双胞胎的形成有影响，这表明增加胚胎分裂易感性的基因在母亲体内表达，而不在受精卵中表达。
