van Staden A M, Barnard H C, Nel M, Attwood E M, Oosthuizen G M, Dannhauser A, van der Ryst E, le Roux G D
Department of Internal Medicine, University of the Orange Free State, Bloemfontein, South Africa.
Cent Afr J Med. 1998 Oct;44(10):246-50.
To evaluate the nutritional status of HIV-1 seropositive patients with regards to laboratory parameters; the correlation between nutrient intake and actual values of nutrients, as well as the relationship between malnutrition and disease progression.
A cross sectional study.
The Immunology Clinic at the Pelonomi Hospital in Bloemfontein, South Africa.
90 HIV/AIDS patients in different stages of disease were recruited consecutively from January to May 1995. Sixteen patients were followed up in 1997.
The patients were divided into three groups according to their CD4+ T-cell counts, and blood levels of protein, albumin, cholesterol, ferritin, vitamin B12, magnesium, and phosphorus, as well as several micronutrients including vitamin E, vitamin C, beta-carotene and retinol which were determined using standard methods. These values were compared with the normal reference values used in the laboratory, and we tried to correlate these parameters with disease stage, as well as recorded nutrient intake in a subgroup of 35 patients.
Abnormal values for several parameters, including plasma-retinol and serum-protein were found, but no correlation between more advanced disease and micronutrient deficiencies could be demonstrated.
HIV/AIDS patients from this population are deficient in several micronutrients, and for some patients this is mirrored by a low intake. Multivitamin/anti-oxidant supplementation of HIV/AIDS patients should be considered, as this could lead to improved immune function in these patients.
根据实验室参数评估HIV-1血清反应阳性患者的营养状况；营养素摄入量与营养素实际值之间的相关性，以及营养不良与疾病进展之间的关系。
一项横断面研究。
南非布隆方丹佩洛诺米医院的免疫诊所。
1995年1月至5月连续招募了90名处于不同疾病阶段的HIV/AIDS患者。1997年对16名患者进行了随访。
根据CD4+ T细胞计数将患者分为三组，并使用标准方法测定血液中蛋白质、白蛋白、胆固醇、铁蛋白、维生素B12、镁和磷的水平，以及几种微量营养素，包括维生素E、维生素C、β-胡萝卜素和视黄醇。将这些值与实验室使用的正常参考值进行比较，并试图将这些参数与疾病阶段以及35名患者亚组中记录的营养素摄入量相关联。
发现包括血浆视黄醇和血清蛋白在内的几个参数值异常，但未发现疾病进展与微量营养素缺乏之间存在相关性。
该人群中的HIV/AIDS患者缺乏几种微量营养素，对于一些患者来说，这反映在摄入量较低上。应考虑对HIV/AIDS患者补充多种维生素/抗氧化剂，因为这可能会改善这些患者的免疫功能。
