Dannhauser A, van Staden A M, van der Ryst E, Nel M, Marais N, Erasmus E, Attwood E M, Barnard H C, le Roux G D
Department of Human Nutrition, University of the Orange Free State, Bloemfontein, South Africa.
Eur J Clin Nutr. 1999 Mar;53(3):165-73. doi: 10.1038/sj.ejcn.1600691.
To evaluate the nutritional intake and status of HIV-1 seropositive patients, as well as the relationship between malnutrition and disease stage.
A cross-sectional study.
The Immunology Clinic at the Pelonomi Hospital in Bloemfontein, South Africa.
Eighty-one HIV/AIDS patients in different stages of disease were recruited consecutively from January to May 1995. Eleven of these patients were followed in 1997.
Anthropometric data including current weight, height, triceps skinfold thickness, mid-upper-arm circumference, body mass index and bone-free arm muscle area were collected. Nutrient intake was estimated using a diet history in combination with a standardised food frequency questionnaire. The patients were divided into 3 groups according to their CD4+ T cell counts.
The men were leaner (BMI = 18.9) than the women (BMI = 22.7) and patients with a CD4+ T cell count < 200 (stage III) tended to have the lowest median values for all anthropometric measurements. More than half the patients had a low intake (< 67% of the recommended dietary allowances) of vitamin C, vitamin B6, vitamin D, vitamin A, calcium, iron and zinc.
The results confirms that HIV/AIDS patients from this population are malnourished. There was, however, no association between disease stage and nutritional status. Nutritional supplementation of HIV/AIDS patients should be considered, as this might lead to improved immune function in these patients.
评估HIV-1血清阳性患者的营养摄入和状况，以及营养不良与疾病阶段之间的关系。
横断面研究。
南非布隆方丹佩洛诺米医院的免疫诊所。
1995年1月至5月连续招募了81名处于不同疾病阶段的HIV/AIDS患者。其中11名患者在1997年接受了随访。
收集人体测量数据，包括当前体重、身高、三头肌皮褶厚度、上臂中部周长、体重指数和无骨手臂肌肉面积。通过饮食史结合标准化食物频率问卷来估计营养摄入量。根据患者的CD4+T细胞计数将其分为3组。
男性（BMI = 18.9）比女性（BMI = 22.7）更瘦，CD4+T细胞计数<200（III期）的患者所有人体测量指标的中位数往往最低。超过一半的患者维生素C、维生素B6、维生素D、维生素A、钙、铁和锌的摄入量较低（<推荐膳食摄入量的67%）。
结果证实该人群中的HIV/AIDS患者存在营养不良。然而，疾病阶段与营养状况之间没有关联。应考虑对HIV/AIDS患者进行营养补充，因为这可能会改善这些患者的免疫功能。
