Kalland K H, Haukenes G
Avdeling for mikrobiologi og immunologi, Gades Institutt, Universitetet, Bergen.
Tidsskr Nor Laegeforen. 1999 Feb 28;119(6):802-9.
The introduction and increasing usage of nucleic acid based methods in clinical microbiology over the last years have contributed to better and earlier diagnosis of infectious diseases as well as more accurate monitoring of treatment. Various nucleic acid amplification methods such as the polymerase chain reaction and the ligase chain reaction are widely used in Norwegian clinical microbiological laboratories to detect fastidious or non-cultured infectious agents. The amplification methods combine an extremely high sensitivity with acceptable specificity. About 200,000 nucleic acid based examinations are now performed in clinical microbiological laboratories in Norway each year.
在过去几年中，基于核酸的方法在临床微生物学中的引入和使用日益增加，这有助于更好、更早地诊断传染病，以及更准确地监测治疗情况。各种核酸扩增方法，如聚合酶链反应和连接酶链反应，在挪威临床微生物学实验室中被广泛用于检测苛养菌或无法培养的感染因子。这些扩增方法结合了极高的灵敏度和可接受的特异性。目前，挪威临床微生物学实验室每年进行约20万次基于核酸的检测。
