Rosengren L E, Karlsson J E, Sjögren M, Blennow K, Wallin A
Institute of Clinical Neuroscience, Department of Neurology, Sahlgrens University Hospital, University of Göteborg, Sweden.
Neurology. 1999 Mar 23;52(5):1090-3. doi: 10.1212/wnl.52.5.1090.
The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is localized mainly in myelinated axons, these results suggest that the degeneration of white matter in these disorders causes the increased CSF NFL levels.
神经丝是有髓轴突的主要细胞骨架结构。在本研究中，与神经功能正常的个体相比，血管性痴呆（VAD）、阿尔茨海默病（AD）和额颞叶痴呆（FTD）患者脑脊液中神经丝蛋白轻链亚基（NFL）水平升高。由于NFL主要定位于有髓轴突，这些结果表明这些疾病中白质的退化导致脑脊液NFL水平升高。
