Tormo R, Potau N, Infante D, Moran J, Martin B, Bergada A
Nutrition and Infant Gastroenterology Unit, Hospital Materno-Infantil Vall d'Hebron, Barcelona, Spain.
Early Hum Dev. 1998 Dec;53 Suppl:S165-72. doi: 10.1016/s0378-3782(98)00073-5.
Cow's milk protein intolerant infants (CMPI), shifted to a cow's milk protein hydrolysate based formula, often experience an improvement in signs of malabsorption; on the other hand, they also present a pattern of watery stools. In an attempt to find high levels of some gastrointestinal hormones that might induce hypermotility, motilin and neurotensin levels were studied in infants on starting formula and in cow's milk protein intolerant infants, on a cow's milk protein hydrolysate based formula. In 12 infants on unmodified cow's milk based formula (starting formula), motilin levels were: mean 71.66 pmol/L (s: 17); neurotensin 26.53 (s: 10.9). In 19 cow's milk protein intolerant infants on a cow's milk protein hydrolysate based formula, motilin levels were: mean 163.65 pmol/L (s: 70.06) (p<0.05); neurotensin: 31.76 pmol/L (s: 15.03) (p>0.05). Motilin (but not neurotensin) is higher in cow's milk protein intolerant infants on a cow's milk protein hydrolysate based formula. We conclude that high motilin levels can induce a different pattern of motility, and can be a pathogenetic factor in the persistence of loose and watery stools in infants with CMPI on a protein hydrolysate based formula.
牛奶蛋白不耐受婴儿（CMPI）改用基于牛奶蛋白水解物的配方奶粉后，吸收不良症状往往会有所改善；另一方面，他们也会出现水样便的情况。为了找出可能导致胃肠动力亢进的某些胃肠激素的高水平，对刚开始食用配方奶粉的婴儿以及食用基于牛奶蛋白水解物配方奶粉的牛奶蛋白不耐受婴儿的胃动素和神经降压素水平进行了研究。在12名食用未改性牛奶配方奶粉（起始配方奶粉）的婴儿中，胃动素水平为：平均71.66 pmol/L（标准差：17）；神经降压素为26.53（标准差：10.9）。在19名食用基于牛奶蛋白水解物配方奶粉的牛奶蛋白不耐受婴儿中，胃动素水平为：平均163.65 pmol/L（标准差：70.06）（p<0.05）；神经降压素：31.76 pmol/L（标准差：15.03）（p>0.05）。食用基于牛奶蛋白水解物配方奶粉的牛奶蛋白不耐受婴儿的胃动素（而非神经降压素）水平更高。我们得出结论，高胃动素水平可诱导不同的动力模式，并且可能是食用基于蛋白水解物配方奶粉的CMPI婴儿持续出现稀便和水样便的发病因素。
