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2
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本文引用的文献

1
In-vitro activity of Sch 29482 in comparison with other oral antibiotics.Sch 29482与其他口服抗生素相比的体外活性。
J Antimicrob Chemother. 1982 Feb;9 Suppl C:143-52. doi: 10.1093/jac/9.suppl_c.143.
2
Transferable beta-lactamase. A new mechanism for in vitro penicillin resistance in Streptococcus faecalis.可转移的β-内酰胺酶。粪肠球菌体外青霉素耐药的一种新机制。
J Clin Invest. 1983 Sep;72(3):1168-71. doi: 10.1172/JCI111042.
3
Comparative in vitro activity of WIN 57273, a new fluoroquinolone antimicrobial agent.新型氟喹诺酮抗菌剂WIN 57273的体外活性比较
Antimicrob Agents Chemother. 1990 Jun;34(6):1154-9. doi: 10.1128/AAC.34.6.1154.
4
Rapid dissemination of beta-lactamase-producing, aminoglycoside-resistant Enterococcus faecalis among patients and staff on an infant-toddler surgical ward.产β-内酰胺酶、耐氨基糖苷类的粪肠球菌在婴幼儿外科病房的患者和医护人员中迅速传播。
N Engl J Med. 1990 Dec 27;323(26):1814-8. doi: 10.1056/NEJM199012273232606.
5
Multicenter evaluation of the in vitro activities of three new quinolones, sparfloxacin, CI-960, and PD 131,628, compared with the activity of ciprofloxacin against 5,252 clinical bacterial isolates.对三种新型喹诺酮类药物（司帕沙星、CI-960和PD 131,628）的体外活性与环丙沙星对5252株临床分离细菌的活性进行多中心评估。
Antimicrob Agents Chemother. 1991 Apr;35(4):764-6. doi: 10.1128/AAC.35.4.764.
6
Comparison of Enterococcus raffinosus with Enterococcus avium on the basis of penicillin susceptibility, penicillin-binding protein analysis, and high-level aminoglycoside resistance.基于青霉素敏感性、青霉素结合蛋白分析及高水平氨基糖苷类耐药性对棉子糖肠球菌和鸟肠球菌的比较
Antimicrob Agents Chemother. 1991 Jul;35(7):1408-12. doi: 10.1128/AAC.35.7.1408.
7
Comparative in vitro activity of PD 127391, a new fluoroquinolone agent, against susceptible and resistant clinical isolates of gram-positive cocci.新型氟喹诺酮类药物PD 127391对革兰氏阳性球菌敏感及耐药临床分离株的体外活性比较
Antimicrob Agents Chemother. 1992 Jun;36(6):1325-8. doi: 10.1128/AAC.36.6.1325.

新型氟喹诺酮类药物CP-99,219对革兰氏阳性菌临床分离株的体外活性

In vitro activity of CP-99,219, a new fluoroquinolone, against clinical isolates of gram-positive bacteria.

作者信息

Eliopoulos G M, Klimm K, Eliopoulos C T, Ferraro M J, Moellering R C

机构信息

Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts 02215.

出版信息

Antimicrob Agents Chemother. 1993 Feb;37(2):366-70. doi: 10.1128/AAC.37.2.366.

DOI:10.1128/AAC.37.2.366
PMID:8452372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC187672/
Abstract

The in vitro activity of the fluoroquinolone CP-99,219 against gram-positive bacteria was compared with those of five other antimicrobial agents. Against ciprofloxacin-susceptible staphylococci and against streptococci, MICs were < or = 0.12 and < or = 0.5 microgram/ml, respectively. CP-99,219 was also more active than ciprofloxacin against ciprofloxacin-resistant staphylococci, most enterococci, Leuconostoc spp., and lactobacilli.

摘要

将氟喹诺酮类药物CP-99,219对革兰氏阳性菌的体外活性与其他五种抗菌剂进行了比较。对于对环丙沙星敏感的葡萄球菌和链球菌，其最小抑菌浓度（MIC）分别≤0.12微克/毫升和≤0.5微克/毫升。CP-99,219对耐环丙沙星的葡萄球菌、大多数肠球菌、明串珠菌属和乳杆菌的活性也高于环丙沙星。