TEM-20、TEM-21、TEM-22和TEM-29超广谱β-内酰胺酶的基因序列。
Sequences of the genes for the TEM-20, TEM-21, TEM-22, and TEM-29 extended-spectrum beta-lactamases.
作者信息
Arlet G, Goussard S, Courvalin P, Philippon A
机构信息
Service de Microbiologie, Hôpital Saint-Louis, Université Paris, France.
出版信息
Antimicrob Agents Chemother. 1999 Apr;43(4):969-71. doi: 10.1128/AAC.43.4.969.
Abstract
The sequences of the blaTEM genes encoding TEM-20, TEM-21, TEM-22, and TEM-29 extended-spectrum beta-lactamases were determined. Analysis of the deduced amino acid sequences indicated that TEM-20 and TEM-29 were derived from TEM-1 and that TEM-21 and TEM-22 were derived from TEM-2. The substitutions involved were Ser-238 and Thr-182 for TEM-20; His-164 for TEM-29; Lys-104, Arg-153, and Ser-238 for TEM-21; and Lys-104, Gly-237, and Ser-238 for TEM-22. The promoter region of the blaTEM-22 gene was identical to that of blaTEM-3. High-level production of TEM-20 could result from a 135-bp deletion which combined the -35 region of the Pa promoter with the -10 region of the P3 promoter and a G-->T transition in the latter motif.
摘要
测定了编码TEM-20、TEM-21、TEM-22和TEM-29超广谱β-内酰胺酶的blaTEM基因序列。对推导的氨基酸序列分析表明，TEM-20和TEM-29源自TEM-1，而TEM-21和TEM-22源自TEM-2。所涉及的替换为：TEM-20的Ser-238和Thr-182；TEM-29的His-164；TEM-21的Lys-104、Arg-153和Ser-238；以及TEM-22的Lys-104、Gly-237和Ser-238。blaTEM-22基因的启动子区域与blaTEM-3的相同。TEM-20的高水平产生可能是由于一个135 bp的缺失，该缺失将Pa启动子的-35区域与P3启动子的-10区域合并，以及后一个基序中的G→T转换。
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