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Extended-spectrum and inhibitor-resistant TEM-type beta-lactamases: mutations, specificity, and three-dimensional structure.

作者信息

Knox J R

机构信息

Department of Molecular and Cell Biology, University of Connecticut, Storrs 06269-3125, USA.

出版信息

Antimicrob Agents Chemother. 1995 Dec;39(12):2593-601. doi: 10.1128/AAC.39.12.2593.

DOI:10.1128/AAC.39.12.2593
PMID:8592985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162995/
Abstract
摘要

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本文引用的文献

1
ANALYSIS BY TRANSDUCTION OF MUTATIONS AFFECTING PENICILLINASE FORMATION IN STAPHYLOCOCCUS AUREUS.通过转导分析影响金黄色葡萄球菌青霉素酶形成的突变
J Gen Microbiol. 1963 Oct;33:121-36. doi: 10.1099/00221287-33-1-121.
2
A catalytically-impaired class A beta-lactamase: 2 A crystal structure and kinetics of the Bacillus licheniformis E166A mutant.一种催化功能受损的A类β-内酰胺酶：地衣芽孢杆菌E166A突变体的2 Å晶体结构与动力学
Protein Eng. 1993 Jan;6(1):11-8. doi: 10.1093/protein/6.1.11.
3
Role of Ser-238 and Lys-240 in the hydrolysis of third-generation cephalosporins by SHV-type beta-lactamases probed by site-directed mutagenesis and three-dimensional modeling.通过定点诱变和三维建模探究Ser-238和Lys-240在SHV型β-内酰胺酶水解第三代头孢菌素中的作用
J Biol Chem. 1993 Feb 15;268(5):3690-7.
4
Crystal structure of Escherichia coli TEM1 beta-lactamase at 1.8 A resolution.分辨率为1.8埃的大肠杆菌TEM1β-内酰胺酶的晶体结构。
Proteins. 1993 Aug;16(4):364-83. doi: 10.1002/prot.340160406.
5
Crystallization of a genetically engineered water-soluble primary penicillin target enzyme. The high molecular mass PBP2x of Streptococcus pneumoniae.一种基因工程改造的水溶性主要青霉素靶酶的结晶。肺炎链球菌的高分子量PBP2x。
J Mol Biol. 1993 Aug 5;232(3):1007-9. doi: 10.1006/jmbi.1993.1452.
6
Characterization of a new TEM-type beta-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli.一株临床分离的大肠杆菌中对克拉维酸、舒巴坦和他唑巴坦耐药的新型TEM型β-内酰胺酶的特性分析
Antimicrob Agents Chemother. 1993 Oct;37(10):2059-63. doi: 10.1128/AAC.37.10.2059.
7
Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase.一种酶活性的演变：阴沟肠杆菌P99 ampC基因头孢菌素酶2埃分辨率的晶体结构及与A类青霉素酶的比较
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11257-61. doi: 10.1073/pnas.90.23.11257.
8
Structure of a phosphonate-inhibited beta-lactamase. An analog of the tetrahedral transition state/intermediate of beta-lactam hydrolysis.一种膦酸酯抑制的β-内酰胺酶的结构。β-内酰胺水解的四面体过渡态/中间体类似物。
J Mol Biol. 1993 Nov 5;234(1):165-78. doi: 10.1006/jmbi.1993.1571.
9
Crystallographic structure of a phosphonate derivative of the Enterobacter cloacae P99 cephalosporinase: mechanistic interpretation of a beta-lactamase transition-state analog.阴沟肠杆菌P99头孢菌素酶膦酸酯衍生物的晶体结构：β-内酰胺酶过渡态类似物的机制解读
Biochemistry. 1994 Jun 7;33(22):6762-72. doi: 10.1021/bi00188a004.
10
A structure-based analysis of the inhibition of class A beta-lactamases by sulbactam.舒巴坦对A类β-内酰胺酶抑制作用的基于结构的分析。
Biochemistry. 1994 May 17;33(19):5728-38. doi: 10.1021/bi00185a009.