由于普里布诺框中的一个点突变，弗氏志贺菌中可转移的TEM-1β-内酰胺酶高产现象
Transferable hyperproduction of TEM-1 beta-lactamase in Shigella flexneri due to a point mutation in the pribnow box.
作者信息
Siu L K, Ho P L, Yuen K Y, Wong S S, Chau P Y
机构信息
Department of Microbiology, Queen Mary Hospital Compound, University of Hong Kong, Hong Kong.
出版信息
Antimicrob Agents Chemother. 1997 Feb;41(2):468-70. doi: 10.1128/AAC.41.2.468.
Abstract
TEM-1 hyperproduction in two ampicillin-sulbactam-resistant Shigella flexneri strains was studied. In both strains the blaTEM gene was encoded as a single copy on a large conjugatively transferable plasmid. A single G-->T transversion at position 1 of the -10 consensus sequence was identified to be the mechanism of TEM-1 hyperproduction.
摘要
对两株耐氨苄西林-舒巴坦的弗氏志贺菌中 TEM-1 超量产生情况进行了研究。在这两株菌中，blaTEM 基因作为单拷贝编码于一个可接合转移的大质粒上。在 -10 共有序列第 1 位的单个 G→T 颠换被确定为 TEM-1 超量产生的机制。
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