影响大鼠颊粘膜复层鳞状上皮有丝分裂率的肾上腺素能因子

Adrenergic factors influencing the mitotic rate in stratified squamous epithelium of the buccal mucosa of the rat.

Hunt H, Tutton P J

Clin Exp Pharmacol Physiol. 1976 May-Jun;3(3):207-15. doi: 10.1111/j.1440-1681.1976.tb02666.x.

Abstract

An in vivo stathmokinetic technique was used to determine the immediate effect of various adrenoceptor agonists and antagonists on the mitotic rate in the stratified squamous epithelium of the rat buccal mucosa. 2. The mitotic rate increased significantly in rats treated with propranolol and with practolol, whereas the mitotic rate decreased significantly in rats treated with metaraminol. In animals treated with isoprenaline and phentolamine the mitotic rate did not differ significantly from the control value. 3. The nature of the involvement of adrenergic mechanisms with cell proliferation is still uncertain but both alpha- and beta-adrenergic mechanisms appear to be associated with the control of cell proliferation.

摘要

采用体内有丝分裂抑制技术来测定各种肾上腺素能受体激动剂和拮抗剂对大鼠颊黏膜复层鳞状上皮有丝分裂率的即时影响。2. 用普萘洛尔和普拉洛尔处理的大鼠，其有丝分裂率显著增加，而用间羟胺处理的大鼠，其有丝分裂率显著降低。用异丙肾上腺素和酚妥拉明处理的动物，其有丝分裂率与对照值无显著差异。3. 肾上腺素能机制参与细胞增殖的性质仍不确定，但α和β肾上腺素能机制似乎都与细胞增殖的控制有关。