生物胺对异种移植的人类结直肠癌生长的影响。
Influence of biogenic amines on the growth of xenografted human colorectal carcinomas.
作者信息
Tutton P J, Steel G G
出版信息
Br J Cancer. 1979 Nov;40(5):743-9. doi: 10.1038/bjc.1979.255.
Abstract
The influence of some biogenic amines and amine-receptor-blocking drugs in the growth rate of human colorectal carcinomas propagated as s.c. xenografts in immune-deprived mice was studied. In mice treated with adrenaline, a beta-adrenergic agonist, the growth of xenografts was suppressed for 2 days, after which growth was resumed at a rate similar to that in control animals. Treatment with the phosphodiesterase inhibitor theophylline prolonged the adrenaline-induced inhibition of growth. Treatment with the beta-adrenergic antagonist sotalol or practolol increased the rate of tumour growth. Treatment with either serotonin or the histamine H2-receptor agonist Dimiprit had no effect on tumour growth rate. However, the antiserotoninergic drug BW 501C and the histamine H2-receptor antagonist cimetidine each caused short-term suppression of tumour growth.
摘要
研究了某些生物胺和胺受体阻断药物对在免疫缺陷小鼠中作为皮下异种移植物生长的人结肠直肠癌生长速率的影响。在用β-肾上腺素能激动剂肾上腺素治疗的小鼠中，异种移植物的生长被抑制了2天，之后以与对照动物相似的速率恢复生长。用磷酸二酯酶抑制剂茶碱治疗可延长肾上腺素诱导的生长抑制。用β-肾上腺素能拮抗剂索他洛尔或心得宁治疗可提高肿瘤生长速率。用5-羟色胺或组胺H2受体激动剂二甲双胍治疗对肿瘤生长速率没有影响。然而，抗5-羟色胺能药物BW 501C和组胺H2受体拮抗剂西咪替丁均引起肿瘤生长的短期抑制。
相似文献
1
Influence of biogenic amines on the growth of xenografted human colorectal carcinomas.生物胺对异种移植的人类结直肠癌生长的影响。
Br J Cancer. 1979 Nov;40(5):743-9. doi: 10.1038/bjc.1979.255.
2
Influence of histamine and serotonin antagonists on the growth of xenografted human colorectal tumors.组胺和5-羟色胺拮抗剂对人结直肠癌异种移植瘤生长的影响。
J Natl Cancer Inst. 1981 Dec;67(6):1207-11.
3
Effects of histamine and 5-hydroxytryptamine on the growth rate of xenografted human bronchogenic carcinomas.组胺和5-羟色胺对异种移植人支气管癌生长速率的影响。
Clin Exp Pharmacol Physiol. 1996 Jun-Jul;23(6-7):465-71. doi: 10.1111/j.1440-1681.1996.tb02762.x.
4
Amine dependence of proliferative activity in two transplantable lines of mouse colonic carcinoma.小鼠结肠癌两个可移植系中增殖活性的胺依赖性
Virchows Arch B Cell Pathol Incl Mol Pathol. 1987;53(3):161-5. doi: 10.1007/BF02890239.
5
Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.血清素摄取抑制剂对肠上皮和结肠直肠癌的影响。
Br J Cancer. 1982 Aug;46(2):260-5. doi: 10.1038/bjc.1982.191.
6
Chemotherapeutic sensitivity of human colorectal tumor xenografts.人结直肠癌异种移植瘤的化疗敏感性
Oncology. 1980;37 Suppl 1:42-50. doi: 10.1159/000225496.
7
Comparison of the tumor inhibiting effects of three histamine H2-receptor antagonists.三种组胺H2受体拮抗剂的抑瘤效果比较
Anticancer Res. 1983 Jan-Feb;3(1):7-10.
8
Variation in response of xenografts of colo-rectal carcinoma to chemotherapy.结直肠癌异种移植对化疗反应的差异。
Br J Cancer. 1978 Apr;37(4):576-84. doi: 10.1038/bjc.1978.87.
9
Experimental chemotherapy of gastrointestinal carcinoma xenografts.胃肠道癌异种移植瘤的实验性化疗
Cancer Treat Rev. 1979 Jun;6 Suppl:43-50. doi: 10.1016/s0305-7372(79)80009-2.
10
Evaluation of single-agent therapy in human colorectal tumour xenografts.人结直肠癌异种移植中单药治疗的评估。
Br J Cancer. 1978 May;37(5):833-40. doi: 10.1038/bjc.1978.122.
引用本文的文献
1
Arylpiperazine Derivatives and Cancer: A New Challenge in Medicinal Chemistry.芳基哌嗪衍生物与癌症：药物化学中的新挑战
Pharmaceuticals (Basel). 2024 Oct 2;17(10):1320. doi: 10.3390/ph17101320.
2
Microbiomics in Collusion with the Nervous System in Carcinogenesis: Diagnosis, Pathogenesis and Treatment.微生物组学在癌症发生过程中与神经系统相互勾结：诊断、发病机制与治疗
Microorganisms. 2021 Oct 11;9(10):2129. doi: 10.3390/microorganisms9102129.
3
Antidepressant Use and Risk of Colorectal Cancer in the Women's Health Initiative.抗抑郁药的使用与妇女健康倡议中结直肠癌的风险。
Cancer Epidemiol Biomarkers Prev. 2018 Aug;27(8):892-898. doi: 10.1158/1055-9965.EPI-17-1035. Epub 2018 May 22.
4
Colorectal cancer risk in relation to antidepressant medication use.结直肠癌风险与抗抑郁药物使用的关系。
Int J Cancer. 2011 Jan 1;128(1):227-32. doi: 10.1002/ijc.25322.
5
Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation.血清素的耗竭和2B受体的选择性抑制通过抑制内皮型一氧化氮合酶和细胞外信号调节激酶1/2磷酸化来抑制肿瘤血管生成。
Neoplasia. 2009 Apr;11(4):408-17. doi: 10.1593/neo.81630.
6
Growth of cultured human glioma tumour cells can be regulated with histamine and histamine antagonists.培养的人脑胶质瘤肿瘤细胞的生长可以用组胺和组胺拮抗剂来调节。
Br J Cancer. 1993 Sep;68(3):475-83. doi: 10.1038/bjc.1993.373.
7
Effects of histamine, H1, H2 and Hic receptor antagonists and alpha-fluoromethylhistidine on the growth of human colorectal cancer in the subrenal capsule assay.组胺、H1、H2和Hic受体拮抗剂以及α-氟甲基组氨酸对人结直肠癌在肾包膜下测定中生长的影响。
Agents Actions. 1994 Jun;41 Spec No:C118-20. doi: 10.1007/BF02007793.
8
Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth.西咪替丁可抑制人结肠癌的体内生长，并逆转组胺刺激的体外和体内生长。
Gut. 1994 Nov;35(11):1632-6. doi: 10.1136/gut.35.11.1632.
9
Influence of prostaglandin analogues on epithelial cell proliferation and xenograft growth.前列腺素类似物对上皮细胞增殖和异种移植物生长的影响。
Br J Cancer. 1980 Jan;41(1):47-51. doi: 10.1038/bjc.1980.6.
10
Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.血清素摄取抑制剂对肠上皮和结肠直肠癌的影响。
Br J Cancer. 1982 Aug;46(2):260-5. doi: 10.1038/bjc.1982.191.
本文引用的文献
1
The pharmacological estimation of adenosine and histamine in blood.血液中腺苷和组胺的药理学评估。
J Physiol. 1935 Aug 22;85(1):1-14. doi: 10.1113/jphysiol.1935.sp003298.
2
Accelerating and decelerating actions of adrenalin on epidermal mitotic activity.肾上腺素对表皮有丝分裂活性的加速和减速作用。
Nature. 1966 May 14;210(5037):715-6. doi: 10.1038/210715a0.
3
The influence of adrenoreceptor activity on crypt cell proliferation in the rat jejunum.肾上腺素能受体活性对大鼠空肠隐窝细胞增殖的影响。
Cell Tissue Kinet. 1974 Mar;7(2):125-36. doi: 10.1111/j.1365-2184.1974.tb00405.x.
4
Evidence for a -adrenergic receptor initiating DNA synthesis in haemopoietic stem cells.α-肾上腺素能受体启动造血干细胞中DNA合成的证据。
Exp Cell Res. 1972 Mar;71(1):228-32. doi: 10.1016/0014-4827(72)90283-2.
5
Cyclic guanosine 3':5'-monophosphate in Escherichia coli and Bacillus lichenformis.大肠杆菌和地衣芽孢杆菌中的环鸟苷 3':5'-单磷酸
J Biol Chem. 1974 Jul 10;249(13):4329-31.
6
Lymphocyte blast transformation. I. Demonstration of adrenergic receptors in human peripheral lymphocytes.淋巴细胞的母细胞转化。I. 人外周血淋巴细胞中肾上腺素能受体的显示。
Cell Immunol. 1970 Dec;1(6):583-95. doi: 10.1016/0008-8749(70)90024-9.
7
A chalone in the mammalian lens. II. Relative effects of adrenaline and noradrenaline on cell division in the rabbit lens.哺乳动物晶状体中的抑素。II. 肾上腺素和去甲肾上腺素对兔晶状体细胞分裂的相对影响。
Exp Eye Res. 1970 Jan;9(1):67-72. doi: 10.1016/s0014-4835(70)80059-8.
8
Beta-adrenergic receptors: evidence for negative cooperativity.β-肾上腺素能受体：负协同性的证据。
Biochem Biophys Res Commun. 1975 Jun 16;64(4):1160-8. doi: 10.1016/0006-291x(75)90815-3.
9
Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites.儿茶酚胺诱导的腺苷酸环化酶亚敏感性与β-肾上腺素能受体结合位点的丧失相关。
Proc Natl Acad Sci U S A. 1975 May;72(5):1945-9. doi: 10.1073/pnas.72.5.1945.
10
Mechanism for histamine H2-receptor induced cell-cycle changes in the bone marrow stem cell.组胺H2受体诱导骨髓干细胞细胞周期变化的机制。
Agents Actions. 1977 Jul;7(2):209-13. doi: 10.1007/BF01969974.
Zotero 插件