McInnes W R, Tutton P J
Virchows Arch B Cell Pathol. 1976 Oct 1;21(4):341-8. doi: 10.1007/BF02899165.
Mitotic rates in the basal layer of cells in the buccal epithelium of rat were measured using a stathmokinetic technique. Adrenaline was found to inhibit cell proliferation in this tissue and the effect of adrenaline could be blocked by the beta-adrenergic antagonist propranolol but not by the alpha-adrenergic antagonist phentolamine nor by the specific beta2-adrenergic antagonist butoxamine. Cell proliferation in the buccal mucosa was also inhibited by terbutaline, a synthetic beta2-adrenergic agonist. The effect of terbutaline was not blocked by either butoxamine or by the specific beta1-adrenergic antagonist practolol.
采用有丝分裂抑制技术测量大鼠颊黏膜上皮基底层细胞的有丝分裂率。发现肾上腺素可抑制该组织中的细胞增殖，肾上腺素的这种作用可被β - 肾上腺素能拮抗剂普萘洛尔阻断，但不能被α - 肾上腺素能拮抗剂酚妥拉明或特异性β2 - 肾上腺素能拮抗剂丁氧胺阻断。合成的β2 - 肾上腺素能激动剂特布他林也可抑制颊黏膜中的细胞增殖。丁氧胺或特异性β1 - 肾上腺素能拮抗剂心得宁均不能阻断特布他林的作用。
