Boquillon M
Lipids. 1976 Dec;11(12):848-52. doi: 10.1007/BF02532991.
A test meal (300 mg casein, 600 mg sucrose, 100 mg corn oil, tracer dose of 9.10(3)H oleic acid) was given to fasting adult rats with intestinal lymph fistulas. One group received an acute oral dose of ethanol (3.2 g/kg body weight) simultaneously with the test meal. Controls received 2.5 ml of water instead of ethanol. Ingestion of ethanol temporarily delayed the removal of lipid radioactivity from the stomachs. More than 25% of radioactivity fed remained 8 hr after feeding whereas with control rats less than 10% of lipid radioactivity fed remained 6 hr after feeding. In controls and ethanol-treated rats, the amounts of exogenous lipids in the intestinal lumen and mucosa were low and similar enough. Quantities of endogenous and exogenous lipids found in the lymph collected during 24 hr after feeding were similar in the two groups, but the fat absorption peak was found after 6 hr in alcoholic rats and before 6 hr in controls. This delay was probably due to the retention of lipids in the stomach. More of the exogenous lipid was always transported by small particles moving in the region of alpha1 globulins in cellulose acetate electrophoresis than by larger particles remaining at the origin. This proportion was enhanced in the ethanol-treated animals. The larger fat particles were richer in endogenous fatty acids in alcohol-treated rats than in controls.
给患有肠淋巴瘘的成年禁食大鼠喂食一顿试验餐（300毫克酪蛋白、600毫克蔗糖、100毫克玉米油、示踪剂量的9.10(3)H油酸）。一组在喂食试验餐的同时给予急性口服剂量的乙醇（3.2克/千克体重）。对照组则给予2.5毫升水而非乙醇。摄入乙醇暂时延迟了胃中脂质放射性的清除。喂食8小时后，超过25%的喂食放射性物质仍留存，而对照大鼠喂食6小时后，留存的脂质放射性物质不到10%。在对照组和乙醇处理组大鼠中，肠腔和黏膜中外源性脂质的量较低且足够相似。喂食后24小时内收集的淋巴中发现的内源性和外源性脂质的量在两组中相似，但酒精处理组大鼠的脂肪吸收峰值出现在6小时后，而对照组则在6小时前。这种延迟可能是由于脂质在胃中的滞留。在醋酸纤维素电泳中，总是有更多的外源性脂质由在α1球蛋白区域移动的小颗粒运输，而不是由留在原点的较大颗粒运输。在乙醇处理的动物中，这一比例有所提高。在酒精处理的大鼠中，较大的脂肪颗粒比较对照组含有更丰富的内源性脂肪酸。
