Rasmussen N J, Rosendal T, Overgaard J
Acta Anaesthesiol Scand. 1978;22(3):257-69. doi: 10.1111/j.1399-6576.1978.tb01300.x.
The effect of althesin 0.5 ml/10 kg on arterial blood pressure, intracranial pressure, cerebral blood flow and oxygen uptake was studied on 19 occasions in 16 patients with varied cerebral pathology. Cerebral blood flow (CBF) was measured using the intracarotid 133xenon method and a 35-channel scintillation detector after cannulation of the internal carotid artery, the internal jugular bulb and the lateral cerebral ventricle. Arterial and intracranial pressures were recorded continuously. Blood gas tensions were measured in simultaneously drawn samples from the internal carotid artery and the jugular bulb. Cerebral oxygen uptake was calculated from the product of CBF and arteriovenous oxygen content difference. Control values were obtained with the patients under a basic general anesthesia, consisting of N2O/O2 pancuronium. The effect of a bolus injection of althesin was then studied 1 and 20 min after the injection. A significant reduction in intracranial pressure, cerebral blood flow and metabolism at 1 min was found to have essentially subsided 20 min after the injection. In patients with focal brain damage, regional flow analysis revealed a paradoxical increase in flow after althesin in the areas corresponding to the focus.
在16例患有不同脑部疾病的患者身上进行了19次研究，观察了每10公斤体重注射0.5毫升阿耳法赛因对动脉血压、颅内压、脑血流量和氧摄取的影响。通过颈内动脉133氙法，在插入颈内动脉、颈内静脉球和侧脑室后，使用35通道闪烁探测器测量脑血流量（CBF）。连续记录动脉压和颅内压。从颈内动脉和颈静脉球同时采集的样本中测量血气张力。脑氧摄取量由脑血流量与动静脉氧含量差的乘积计算得出。在患者处于由N2O/O2泮库溴铵组成的基础全身麻醉状态下获取对照值。然后在注射阿耳法赛因1分钟和20分钟后研究单次推注的效果。发现在注射后1分钟时颅内压、脑血流量和代谢显著降低，而在注射20分钟后基本消退。在患有局灶性脑损伤的患者中，区域血流分析显示，在与病灶相对应的区域，阿耳法赛因注射后血流出现反常增加。
