Orgogozo J M, Renou A M, Vernhiet J, Caillé J M, Loiseau P
Rev Electroencephalogr Neurophysiol Clin. 1977 Jan-Mar;7(1):98-104. doi: 10.1016/s0370-4475(77)80041-5.
The effect of Althesin on local blood flow in the brain was studied using intra-carotid Xenon 133 in 18 subjects: 6 apparently normal, 6 with diffuse cerebro-vascular pathology, and 6 cases of ischaemic cerebral accidents identified by scintigraphy, tomodensitometry and angiography. Blood flow decreased under Althesin in the first 2 groups, although to a lesser extent in the second group, with a concomitant decrease in oxygen metabolism. In the third group a "paradoxical" increase in blood flow was observed in infarcts, and a decrease proportional to the rest of the brain in limited ischaemia which had subsequently regressed. The "Althesin test" proposed by Rasmussen (1975) thus reveals the existence of a disconnection between blood flow and metabolism within cerebral infarcts, and provides a possible means of differentiating the latter from reversible ischaemias.
使用颈内注射氙133的方法，对18名受试者进行了研究，以观察阿尔泰辛对大脑局部血流的影响。这18名受试者分为三组：6名看似正常，6名患有弥漫性脑血管病变，6名经闪烁扫描、计算机断层扫描和血管造影确诊为缺血性脑卒。在前两组中，使用阿尔泰辛后血流减少，尽管第二组减少程度较小，同时氧代谢也降低。在第三组中，在梗死灶中观察到血流“反常”增加，在局限性缺血区域血流减少程度与大脑其他部位成比例，随后缺血情况有所缓解。因此，拉斯穆森（1975年）提出的“阿尔泰辛试验”揭示了脑梗死区域血流与代谢之间存在脱节现象，并提供了一种区分脑梗死与可逆性缺血的可能方法。
