Sacks D L, Todd W J, Macdonald A B
Clin Exp Immunol. 1978 Jul;33(1):57-64.
The first temporal study of the cell-mediated immune responses (CMI) following ocular infections with Chlamydia trachomatis is presented. We examined the CMI of owl monkeys infected with trachoma to soluble antigens of C. trachomatis by leucocyte migration inhibition (LIF) and delayed hypersensitivity skin testing. Delayed hypersensitivity of a systemic nature developed after a local eye infection in owl monkeys; clearance of inclusions from conjunctival cells coincided with the onset of this response. The association of eye secretion and circulating antibodies with recovery from primary infection was not so striking. Both cellular and humoral immune responses persisted for at least 2 months, at which time all test animals were completely resistant to re-infection. The elicitation of cell-mediated immune reactions with solubilized chlamydial antigens may permit the isolation of specific antigens involved in the generation of protective immunity in the owl monkey model.
本文首次对沙眼衣原体眼部感染后的细胞介导免疫反应（CMI）进行了时间研究。我们通过白细胞迁移抑制试验（LIF）和迟发型超敏皮肤试验，检测了感染沙眼的猫头鹰猴对沙眼衣原体可溶性抗原的CMI。猫头鹰猴局部眼部感染后出现了全身性迟发型超敏反应；结膜细胞内包涵体的清除与该反应的开始同时发生。眼部分泌物和循环抗体与原发性感染恢复之间的关联并不那么显著。细胞免疫和体液免疫反应至少持续了2个月，此时所有受试动物对再次感染均具有完全抵抗力。用溶解的衣原体抗原引发细胞介导的免疫反应，可能有助于在猫头鹰猴模型中分离出参与产生保护性免疫的特异性抗原。
