MacDonald A B, McComb D, Howard L
J Infect Dis. 1984 Mar;149(3):439-42. doi: 10.1093/infdis/149.3.439.
The conjunctivae of owl monkeys were topically vaccinated with purified Chlamydia trachomatis organisms that had been inactivated by 60Co irradiation and lyophilized onto an inert carrier. Vaccinated monkeys developed antibody in serum and tears, while control animals given a placebo had no detectable titers. When challenged 35 days after the start of administration of the vaccine, all monkeys showed evidence of infection. The vaccinated group had a longer course of disease and more ocular discharge than did controls. Antibody levels in both serum and tears were nearly 10-fold higher after infection in vaccinated animals than in controls.
将经60Co辐照灭活并冻干在惰性载体上的纯化沙眼衣原体菌株局部接种于夜猴的结膜。接种疫苗的猴子血清和泪液中产生了抗体，而给予安慰剂的对照动物未检测到抗体效价。在开始接种疫苗35天后进行攻毒时，所有猴子均出现感染迹象。接种疫苗组的病程比对照组更长，眼部分泌物也更多。接种疫苗的动物感染后血清和泪液中的抗体水平比对照组高近10倍。
