酮洛芬及其他几种非甾体抗炎药对“RCS”的抑制活性与前列腺素合成及抗炎活性之间的关系。
Relationship between the inhibitory activity on 'RCS' and prostaglandins synthesis and the anti-inflammatory activity of ketoprofen and several other non-steroidal anti-inflammatory agents.
作者信息
Guyonnet J C, Julou L
出版信息
Rheumatol Rehabil. 1976;Suppl:11-4. doi: 10.1093/rheumatology/15.5.11.
PMID:1013579
Abstract
In this study ketoprofen has been shown to be the most potent of all anti-inflammatory drugs in inhibiting the synthesis of prostaglandins and the 'rabbit-aorta contracting substance' (RCS), using the guinea-pig lung preparation. Although there did not appear to be a close relationship between the activities of the various drugs in inhibiting prostaglandins synthesis and in their anti-inflammatory activity, the compounds were ranked in the same order in both test systems.
摘要
在本研究中，通过豚鼠肺制备实验表明，在抑制前列腺素和“兔主动脉收缩物质”（RCS）的合成方面，酮洛芬是所有抗炎药物中最有效的。虽然各种药物在抑制前列腺素合成方面的活性与其抗炎活性之间似乎没有密切关系，但在这两个测试系统中，这些化合物的排名顺序相同。
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