化学或机械刺激豚鼠肺诱导兔主动脉收缩物质（RCS）和前列腺素的释放。
Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs.
作者信息
Palmer M A, Piper P J, Vane J R
出版信息
Br J Pharmacol. 1973 Oct;49(2):226-42. doi: 10.1111/j.1476-5381.1973.tb08368.x.
Abstract
- Rabbit aorta contracting substance (RCS) and prostaglandins were released from guinea-pig isolated perfused lungs by gentle massage and also by infusion of Prosparol.2. RCS and prostaglandins were also released by infusion into the pulmonary artery of bradykinin, arachidonic and dihomo-gamma-linolenic acids or shock perfusate (containing RCS-releasing factor).3. Arachidonic and dihomo-gamma-linolenic acids caused a prolonged release of RCS and prostaglandins whereas bradykinin and shock perfusate gave a short-lasting output.4. RCS and prostaglandins, together with histamine were released when superfused chopped lung tissue was agitated.5. Challenge of sensitized guinea-pigs in vivo led to the release of an RCS-like substance into the carotid arterial blood.6. Intravenous injection of bradykinin into guinea-pigs also released an RCS-like substance.7. The release of RCS and prostaglandins was inhibited by aspirin or indomethacin in all experiments.8. RCS contracted all vascular tissues investigated and also rat stomach strip.9. The half-life of RCS was estimated as 1-2 minutes.
摘要
通过轻柔按摩以及输注保栓通，从豚鼠离体灌注肺中释放出兔主动脉收缩物质（RCS）和前列腺素。
通过向肺动脉输注缓激肽、花生四烯酸和二高-γ-亚麻酸或休克灌注液（含RCS释放因子），也可释放出RCS和前列腺素。
花生四烯酸和二高-γ-亚麻酸可导致RCS和前列腺素的持续释放，而缓激肽和休克灌注液的释放则是短暂的。
当对切碎的肺组织进行表面灌注并搅拌时，RCS、前列腺素以及组胺会被释放出来。
对致敏豚鼠进行体内激发会导致一种类似RCS的物质释放到颈动脉血液中。
向豚鼠静脉注射缓激肽也会释放出一种类似RCS的物质。
在所有实验中，阿司匹林或吲哚美辛均可抑制RCS和前列腺素的释放。
RCS可使所有研究的血管组织以及大鼠胃条收缩。
RCS的半衰期估计为1 - 2分钟。
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