• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

化学或机械刺激豚鼠肺诱导兔主动脉收缩物质（RCS）和前列腺素的释放。

Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs.

作者信息

Palmer M A, Piper P J, Vane J R

出版信息

Br J Pharmacol. 1973 Oct;49(2):226-42. doi: 10.1111/j.1476-5381.1973.tb08368.x.

DOI:10.1111/j.1476-5381.1973.tb08368.x
PMID:4135341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776376/
Abstract
  1. Rabbit aorta contracting substance (RCS) and prostaglandins were released from guinea-pig isolated perfused lungs by gentle massage and also by infusion of Prosparol.2. RCS and prostaglandins were also released by infusion into the pulmonary artery of bradykinin, arachidonic and dihomo-gamma-linolenic acids or shock perfusate (containing RCS-releasing factor).3. Arachidonic and dihomo-gamma-linolenic acids caused a prolonged release of RCS and prostaglandins whereas bradykinin and shock perfusate gave a short-lasting output.4. RCS and prostaglandins, together with histamine were released when superfused chopped lung tissue was agitated.5. Challenge of sensitized guinea-pigs in vivo led to the release of an RCS-like substance into the carotid arterial blood.6. Intravenous injection of bradykinin into guinea-pigs also released an RCS-like substance.7. The release of RCS and prostaglandins was inhibited by aspirin or indomethacin in all experiments.8. RCS contracted all vascular tissues investigated and also rat stomach strip.9. The half-life of RCS was estimated as 1-2 minutes.
摘要

  1. 通过轻柔按摩以及输注保栓通，从豚鼠离体灌注肺中释放出兔主动脉收缩物质（RCS）和前列腺素。

  2. 通过向肺动脉输注缓激肽、花生四烯酸和二高-γ-亚麻酸或休克灌注液（含RCS释放因子），也可释放出RCS和前列腺素。

  3. 花生四烯酸和二高-γ-亚麻酸可导致RCS和前列腺素的持续释放，而缓激肽和休克灌注液的释放则是短暂的。

  4. 当对切碎的肺组织进行表面灌注并搅拌时，RCS、前列腺素以及组胺会被释放出来。

  5. 对致敏豚鼠进行体内激发会导致一种类似RCS的物质释放到颈动脉血液中。

  6. 向豚鼠静脉注射缓激肽也会释放出一种类似RCS的物质。

  7. 在所有实验中，阿司匹林或吲哚美辛均可抑制RCS和前列腺素的释放。

  8. RCS可使所有研究的血管组织以及大鼠胃条收缩。

  9. RCS的半衰期估计为1 - 2分钟。

相似文献

1
Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs.化学或机械刺激豚鼠肺诱导兔主动脉收缩物质（RCS）和前列腺素的释放。
Br J Pharmacol. 1973 Oct;49(2):226-42. doi: 10.1111/j.1476-5381.1973.tb08368.x.
2
Prostaglandin endoperoxides IX. Characterization of rabbit aorta contracting substance (RCS) from guinea pig lung and human platelets.前列腺素内过氧化物IX。豚鼠肺和人血小板中兔主动脉收缩物质（RCS）的特性。
Acta Physiol Scand. 1975 Jun;94(2):222-8. doi: 10.1111/j.1748-1716.1975.tb05881.x.
3
Release of smooth muscle-contracting substances from isolated perfused lungs.从离体灌注肺中释放平滑肌收缩物质。
Eur J Pharmacol. 1976 Feb;35(2):349-60. doi: 10.1016/0014-2999(76)90238-7.
4
The release of prostaglandins and thromboxanes from guinea-pig lung by slow reacting substance of anaphylaxis, and its inhibition.豚鼠肺中过敏反应迟缓反应物质释放前列腺素和血栓素及其抑制作用
Br J Pharmacol. 1978 Oct;64(2):211-8. doi: 10.1111/j.1476-5381.1978.tb17291.x.
5
Inhibition by non-steroidal anti-inflammatory agents of the release of rabbit aorta contracting substance and prostaglandins from chopped guinea-pig lungs.非甾体抗炎药对豚鼠肺组织匀浆释放兔主动脉收缩物质及前列腺素的抑制作用
J Pharm Pharmacol. 1974 Jun;26(6):448-51. doi: 10.1111/j.2042-7158.1974.tb09311.x.
6
The release of spasmogenic substances from human chopped lung tissue and its inhibition.人肺组织匀浆中致痉物质的释放及其抑制作用
Br J Pharmacol. 1973 Feb;47(2):291-304. doi: 10.1111/j.1476-5381.1973.tb08327.x.
7
The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs.前列腺素和兔主动脉收缩物质（RCS）从兔脾脏中的释放及其被抗炎药物的拮抗作用。
Br J Pharmacol. 1972 May;45(1):37-47. doi: 10.1111/j.1476-5381.1972.tb09574.x.
8
Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig.皮质类固醇抑制前列腺素从兔灌注肠系膜血管和致敏豚鼠灌注肺中释放。
Prostaglandins. 1975 Aug;10(2):343-55. doi: 10.1016/0090-6980(75)90053-2.
9
Evidence for functionally distinct pools of phospholipase responsible for prostaglandin release from the perfused guinea-pig lung.负责从灌注的豚鼠肺中释放前列腺素的磷脂酶功能不同池的证据。
Eur J Pharmacol. 1980 Jun 27;64(4):333-9. doi: 10.1016/0014-2999(80)90241-1.
10
Selective inhibition by mepacrine of the release of "rabbit aorta contracting substance" evoked by the administration of bradykinin.米帕林对缓激肽给药引起的“兔主动脉收缩物质”释放的选择性抑制作用。
J Pharm Pharmacol. 1972 Feb;24(2):159-61. doi: 10.1111/j.2042-7158.1972.tb08953.x.

引用本文的文献

1
Actions and interactions of bradykinin, prostaglandins, and nonsteroidal antiinflammatory agents on the eye.缓激肽、前列腺素和非甾体抗炎药对眼睛的作用和相互作用。
Inflammation. 1976 Mar;1(2):117-25. doi: 10.1007/BF00917523.
2
Bioassay of prostacyclin and endothelium-derived relaxing factor (EDRF) from porcine aortic endothelial cells. 1985.猪主动脉内皮细胞中前列环素和内皮源性舒张因子（EDRF）的生物测定。1985年。
Br J Pharmacol. 1997 Feb;120(4 Suppl):494-503; discussion 491-3. doi: 10.1111/j.1476-5381.1997.tb06839.x.
3
Involvement of cyclo-oxygenase-generated vasodilating eicosanoid(s) in addition to nitric oxide in endothelin-1-induced endothelium-dependent vasorelaxation in guinea pig aorta.除一氧化氮外，环氧化酶生成的血管舒张类花生酸在豚鼠主动脉内皮素-1诱导的内皮依赖性血管舒张中的作用。
Heart Vessels. 1993;8(3):121-7. doi: 10.1007/BF01744796.
4
Role played by NK2 receptor and cyclooxygenase activation in bradykinin B2 receptor mediated-airway effects in guinea pigs.NK2受体和环氧合酶激活在豚鼠缓激肽B2受体介导的气道效应中所起的作用。
Agents Actions. 1993 Jul;39(3-4):111-7. doi: 10.1007/BF01998962.
5
Mechanisms underlying enhanced responses of J receptors of cats to excitants in pulmonary oedema.猫肺水肿时J受体对兴奋剂反应增强的潜在机制。
J Physiol. 1993 Nov;471:535-47. doi: 10.1113/jphysiol.1993.sp019914.
6
Actions of endothelins and sarafotoxin 6c in the rat isolated perfused lung.内皮素和6c型芋螺毒素在大鼠离体灌注肺中的作用。
Br J Pharmacol. 1995 Jun;115(4):653-9. doi: 10.1111/j.1476-5381.1995.tb14982.x.
7
The metabolism of arachidonic acid in the isolated tracheal and lung strip preparations of guinea-pigs.豚鼠离体气管和肺条制备物中花生四烯酸的代谢
Lung. 1980;158(3):121-9. doi: 10.1007/BF02713714.
8
Contribution of prostaglandins and thromboxanes to the adenosine and ATP-induced contraction of guinea-pig isolated trachea.前列腺素和血栓素对豚鼠离体气管中腺苷和ATP诱导收缩的作用。
Br J Pharmacol. 1982 Sep;77(1):39-44. doi: 10.1111/j.1476-5381.1982.tb09266.x.
9
Studies on the regulation of secretion in Clara cells with evidence for chemical nonautonomic mediation of the secretory response to increased ventilation in rat lungs.关于克拉拉细胞分泌调节的研究，有证据表明大鼠肺脏对通气增加的分泌反应存在化学性非自主调节。
J Clin Invest. 1982 Sep;70(3):608-13. doi: 10.1172/jci110653.
10
Tromboxane B2 inhibits the pulmonary inactivation of prostaglandin E2 in the dog.血栓素B2抑制犬体内前列腺素E2的肺部失活。
Br J Pharmacol. 1980 Oct;70(2):295-9. doi: 10.1111/j.1476-5381.1980.tb07935.x.

本文引用的文献

1
THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD.利用离体器官检测循环血液中的活性物质
Br J Pharmacol Chemother. 1964 Oct;23(2):360-73. doi: 10.1111/j.1476-5381.1964.tb01592.x.
2
PROSTAGLANDINS AND RELATED FACTORS: XIX. THIN-LAYER CHROMATOGRAPHY OF PROSTAGLANDINS.前列腺素及相关因子：十九。前列腺素的薄层色谱法。
J Lipid Res. 1964 Jan;5:117-20.
3
[Hydrogen peroxide as the carrier of the intestinal stimulating effect of polyunsturated fatty acids].[过氧化氢作为多不饱和脂肪酸肠道刺激作用的载体]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1962;243:174-86.
4
Analgesic antipyretic drugs as antagonists of bradykinin.作为缓激肽拮抗剂的解热镇痛药。
Br J Pharmacol Chemother. 1960 Dec;15(4):601-10. doi: 10.1111/j.1476-5381.1960.tb00288.x.
5
Prostaglandins: their disappearance from and release into the circulation.前列腺素：它们在循环系统中的消失与释放
Nature. 1967 Dec 2;216(5118):868-73. doi: 10.1038/216868a0.
6
The release of rabbit aorta contracting substance (RCS) from chopped lung and its antagonism by anti-inflammatory drugs.兔主动脉收缩物质（RCS）从切碎的肺组织中的释放及其被抗炎药物的拮抗作用。
Br J Pharmacol. 1970 Nov;40(3):581P-582P.
7
Release of vaso-active substances from lungs by injection of particles.通过注射颗粒从肺部释放血管活性物质。
Br J Pharmacol. 1970 Nov;40(3):547P-548P.
8
Release of prostaglandins from embolized lungs.栓塞肺组织中前列腺素的释放。
Br J Surg. 1970 Oct;57(10):738-41. doi: 10.1002/bjs.1800571011.
9
Indomethacin and aspirin abolish prostaglandin release from the spleen.吲哚美辛和阿司匹林可抑制前列腺素从脾脏释放。
Nat New Biol. 1971 Jun 23;231(25):237-9. doi: 10.1038/newbio231237a0.
10
Aspirin selectively inhibits prostaglandin production in human platelets.阿司匹林可选择性抑制人体血小板中前列腺素的生成。
Nat New Biol. 1971 Jun 23;231(25):235-7. doi: 10.1038/newbio231235a0.