非甾体抗炎药对慢反应物质C在血液中产生的兔主动脉收缩活性的抑制作用。
Inhibition by non-steroid anti-inflammatory agents of rabbit aorta contracting activity generated in blood by slow reacting substance C.
作者信息
Ferreira S H, Vargaftig B B
出版信息
Br J Pharmacol. 1974 Apr;50(4):543-51. doi: 10.1111/j.1476-5381.1974.tb08587.x.
1 A crude and a partially purified preparation of slow reacting substance C (SRS-C) as well as arachidonic acid decreased resistance to perfusion of the dog hind paw. This effect was suppressed by treatment with non-steroid anti-inflammatory drugs.2 Injections of SRS-C or of arachidonic acid induced marked and reproducible contractions of strips of rabbit aorta and a rat stomach which were bathed in blood from an anaesthetized dog. The effect on the rabbit aorta is attributed to formation of a rabbit aorta contracting substance (RCS). The contractions were suppressed when the dog was treated with a non-steroid anti-inflammatory drug.3 Incubation of blood or of platelet-rich plasma with SRS-C or arachidonic acid resulted in the formation of similar materials. This formation was suppressed by anti-inflammatory drugs.4 SRS-C, linoleic, linolenic, and arachidonic acids are suitable substrates for soybean lipoxidase for the generation of RCS.5 It is suggested that RCS and prostaglandin are formed within platelets, when SRS-C or arachidonic acid are injected into animals or added in vitro. Non-steroid anti-inflammatory drugs suppress these effects, possibly by inhibiting prostaglandin synthetase.
粗制的和部分纯化的慢反应物质C（SRS - C）制剂以及花生四烯酸均可降低犬后爪的灌注阻力。这种效应可被非甾体抗炎药抑制。
注射SRS - C或花生四烯酸可引起兔主动脉条和大鼠胃条显著且可重复的收缩，这些组织条浸浴在来自麻醉犬的血液中。对兔主动脉的效应归因于兔主动脉收缩物质（RCS）的形成。当犬用非甾体抗炎药治疗时，收缩被抑制。
血液或富含血小板的血浆与SRS - C或花生四烯酸孵育会导致形成类似物质。这种形成被抗炎药抑制。
SRS - C、亚油酸、亚麻酸和花生四烯酸是大豆脂氧化酶生成RCS的合适底物。
有人提出，当将SRS - C或花生四烯酸注射到动物体内或在体外添加时，RCS和前列腺素在血小板内形成。非甾体抗炎药可能通过抑制前列腺素合成酶来抑制这些效应。
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