直肠活检材料中前列腺素合成酶活性的测定及其在结肠疾病中的意义。
Determination of prostaglandin synthetase activity in rectal biopsy material and its significance in colonic disease.
作者信息
Harris D W, Smith P R, Swan C H
出版信息
Gut. 1978 Oct;19(10):875-7. doi: 10.1136/gut.19.10.875.
Abstract
A method is described for determining prostaglandin synthetase activity in milligram amounts of tissue. The procedure is based on the conversion of 14C-arachidonic acid to prostaglandin E2 and F2alpha-like substances. High levels of prostaglandin synthetase activity occurred in the inflamed mucosa of patients with ulcerative colitis and fell during successful drug therapy, but it is not yet known whether the cause of the inflammation first involves increased PG synthetase activity, or whether inflammation caused increase of PG synthetase.
摘要
本文描述了一种用于测定毫克量组织中前列腺素合成酶活性的方法。该方法基于将14C-花生四烯酸转化为前列腺素E2和F2α样物质。溃疡性结肠炎患者炎症黏膜中前列腺素合成酶活性水平较高，且在成功的药物治疗过程中下降，但目前尚不清楚炎症的起因是首先涉及前列腺素合成酶活性增加，还是炎症导致了前列腺素合成酶的增加。
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