Taylor D W, Siddiqui W A
Infect Immun. 1978 Jul;21(1):147-50. doi: 10.1128/iai.21.1.147-150.1978.
Plasma collected from owl monkeys during the acute phase of Plasmodium falciparum infection was shown to adversely affect several in vitro responses which are considered to be correlates of cell-mediated immune functions of normal monkeys. In the presence of acute-phase plasma, response of normal monkey peripheral blood lymphocytes to stimulation with phytohemagglutinin, concanavalin A, and pokeweed mitogen was severely reduced, as was the ability of peripheral blood lymphocytes to respond to allogenic and xenogenic histocompatible antigens. The transformation response of peripheral blood lymphocytes from normal humans to phytohemagglutinin and concanavalin A was also suppressed. Since acute-phase plasma was not cytotoxic for peripheral blood lymphocytes, decreased responsiveness did not result from cell destruction. Acute-phase plasma appears to block initial steps in lymphocyte transformation.
在恶性疟原虫感染急性期从夜猴采集的血浆被证明会对几种体外反应产生不利影响，这些反应被认为是正常猴子细胞介导免疫功能的相关指标。在急性期血浆存在的情况下，正常猴子外周血淋巴细胞对植物血凝素、刀豆球蛋白A和商陆有丝分裂原刺激的反应严重降低，外周血淋巴细胞对同种异体和异种组织相容性抗原的反应能力也降低。正常人外周血淋巴细胞对植物血凝素和刀豆球蛋白A的转化反应也受到抑制。由于急性期血浆对外周血淋巴细胞无细胞毒性，反应性降低并非由细胞破坏所致。急性期血浆似乎会阻断淋巴细胞转化的初始步骤。
