A review: secondary ion mass spectrometry (SIMS) of polymeric biomaterials.

This paper comprises a short review of the application of secondary ion mass spectrometry (SIMS) to the surface chemical analysis of biomaterials, with the main emphasis on biomedical polymers. By the use of appropriate examples, the technique is shown to provide detailed information on the surface chemical structure of the top 1-2 nm of a range of biodegradable polymers, copolymers, surface modified materials and drug delivery systems. Semi-quantitative information on the surface composition of copolymeric materials can also be obtained. The molecular specificity of the technique can be exploited to identify the presence of additives (eg. drugs, peptides) or contaminants in the surfaces of biomaterials. This approach can be extended to situations where biomolecules of interest are covalently immobilised on biomaterial surfaces. Finally, SIMS imaging analysis is shown to provide a means of determining the lateral distribution of additive molecules in surfaces.