28千赫兹和160千赫兹干扰素-α超声雾化的比较。

A comparison of 28kHz- and 160kHz- ultrasonic aerosolization of interferon-alpha.

作者信息

Sato Y, Sato M, Kita M, Kishida T

机构信息

Department of Medical Technology, Kobe Tokiwa College.

出版信息

J Aerosol Med. 1992 Summer;5(2):59-64. doi: 10.1089/jam.1992.5.59.

DOI:10.1089/jam.1992.5.59

PMID:10147684

Abstract

The efficacy and utility of interferon (IFN) in prophylaxis and treatment of nasal infections have been evaluated in recent investigation. In our basic studies on aerosolization of IFN, we examined the effect of aerosolization on IFN-alpha activity utilizing an ultrasonic inhaler (NE-U05). The effect of ultrasonic treatment (28kHz) on IFN activity was also studied. IFN activity was determined by a conventional cytopathic effect inhibition assay. Although IFN-alpha activity was partially inactivated at a specific frequency of 28kHz, it was not affected by ultrasonic treatment (160kHz) from the ultrasonic inhaler. These results show that the aerosolization of IFN-alpha by the ultrasonic inhaler can be recommended for clinical use without inactivation of IFN-alpha activity.

摘要

近期研究评估了干扰素（IFN）在预防和治疗鼻腔感染中的疗效和实用性。在我们关于IFN雾化的基础研究中，我们使用超声雾化器（NE-U05）研究了雾化对IFN-α活性的影响。还研究了超声处理（28kHz）对IFN活性的影响。IFN活性通过传统的细胞病变效应抑制试验来测定。尽管IFN-α活性在特定的28kHz频率下部分失活，但它不受超声雾化器超声处理（160kHz）的影响。这些结果表明，超声雾化器雾化IFN-α可推荐用于临床，而不会使IFN-α活性失活。