Kawashita Masakazu, Sadaoka Kazuo, Kokubo Tadashi, Saito Takashi, Takano Mikio, Araki Norio, Hiraoka Masahiro
Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan.
J Mater Sci Mater Med. 2006 Jul;17(7):605-10. doi: 10.1007/s10856-006-9222-x.
Ferrimagnetic materials can be expected to be useful as thermal seeds for hyperthermic treatment of cancer, especially where the cancer is located in deep parts of body, as they can generate heat by magnetic hysteretic loss when they are placed in an alternating magnetic field. In this study, hollow magnetite (Fe(3)O(4)) particles were prepared using an enzymatic reaction of urease. A hollow particle was obtained by using a Pasteur pipette. The particle was 500 microm in size and was composed of Fe(3)O(4). Its saturation magnetization and coercive force were 57 emuxg(-1) and 183 Oe, respectively. Its heat generation under an alternating magnetic field of 300 Oe at 100 kHz was estimated to be 45 Wxg(-1). Microspheres 30 microm in diameter were also successfully obtained by using a spray gun.
铁磁材料有望作为癌症热疗的热种子，特别是当癌症位于身体深部时，因为当它们置于交变磁场中时，可通过磁滞损耗产生热量。在本研究中，利用脲酶的酶促反应制备了空心磁铁矿（Fe(3)O(4)）颗粒。通过巴斯德吸管获得了空心颗粒。该颗粒尺寸为500微米，由Fe(3)O(4)组成。其饱和磁化强度和矫顽力分别为57 emu·g(-1)和183 Oe。在100 kHz、300 Oe的交变磁场下，其发热估计为45 W·g(-1)。使用喷枪也成功获得了直径为30微米的微球。
