College of Medical Technology and Engineering, Henan University of Science and Technology, Luo Yang, 471003, Henan, People's Republic of China.
J Mater Sci Mater Med. 2011 Oct;22(10):2197-206. doi: 10.1007/s10856-011-4417-1. Epub 2011 Aug 26.
Magnetic bioactive glass ceramic (MG) in the system CaO-SiO(2)-P(2)O(5)-MgO-CaF(2)-MnO(2)-Fe(2)O(3) for hyperthermia treatment of bone tumor was synthesized. The phase composition was investigated by XRD. The magnetic property was measured by VSM. The in vitro bioactivity was investigated by simulated body fluid (SBF) soaking experiment. Cell growth on the surface of the material was evaluated by co-culturing osteoblast-like ROS17/2.8 cells with materials for 7 days. The results showed that MG contained CaSiO(3) and Ca(5)(PO(4))(3)F as the main phases, and MnFe(2)O(4) and Fe(3)O(4) as the magnetic phases. Under a magnetic field of 10,000 Oe, the saturation magnetization and coercive force of MG were 6.4 emu/g and 198 Oe, respectively. After soaking in SBF for 14 days, hydroxyapatite containing CO(3)(2-) was observed on the surface of MG. The experiment of co-culturing cells with material showed that cells could successfully attach and well proliferate on MG.
用于骨肿瘤热疗的 CaO-SiO(2)-P(2)O(5)-MgO-CaF(2)-MnO(2)-Fe(2)O(3) 体系的磁性生物活性玻璃陶瓷 (MG) 被合成。通过 XRD 研究了其物相组成。通过 VSM 测量了其磁性。通过模拟体液 (SBF) 浸泡实验研究了其体外生物活性。通过将成骨样 ROS17/2.8 细胞与材料共培养 7 天，评估了细胞在材料表面的生长情况。结果表明，MG 含有 CaSiO(3) 和 Ca(5)(PO(4))(3)F 作为主要相，以及 MnFe(2)O(4) 和 Fe(3)O(4) 作为磁性相。在磁场强度为 10000 Oe 时，MG 的饱和磁化强度和矫顽力分别为 6.4 emu/g 和 198 Oe。在 SBF 中浸泡 14 天后，MG 表面观察到含有 CO(3)(2-) 的羟基磷灰石。与材料共培养细胞的实验表明，细胞可以成功附着并在 MG 上良好增殖。
