Matsuoka Fumiko, Shinkai Masashige, Honda Hiroyuki, Kubo Tadahiko, Sugita Takashi, Kobayashi Takeshi
Department of Biotechnology, School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
Biomagn Res Technol. 2004 Mar 25;2(1):3. doi: 10.1186/1477-044X-2-3.
We have developed magnetite cationic liposomes (MCLs) and applied them to local hyperthermia as a mediator. MCLs have a positive charge and generate heat under an alternating magnetic field (AMF) by hysteresis loss. In this study, the effect of hyperthermia using MCLs was examined in an in vivo study of hamster osteosarcoma. METHOD: MCLs were injected into the osteosarcoma and then subjected to an AMF. RESULTS: The tumor was heated at over 42 degrees C, but other normal tissues were not heated as much. Complete regression was observed in 100% of the treated group hamsters, whereas no regression was observed in the control group hamsters. At day 12, the average tumor volume of the treated hamsters was about 1/1000 of that of the control hamsters. In the treated hamsters, no regrowth of osteosarcomas was observed over a period of 3 months after the complete regression. CONCLUSION: These results suggest that this treatment is effective for osteosarcoma.
我们研发了磁性阳离子脂质体（MCLs）并将其作为一种介质应用于局部热疗。MCLs带正电荷，在交变磁场（AMF）作用下通过磁滞损耗产热。在本研究中，在仓鼠骨肉瘤的体内研究中检测了使用MCLs进行热疗的效果。
将MCLs注入骨肉瘤，然后施加AMF。
肿瘤被加热到42摄氏度以上，但其他正常组织未被加热到如此程度。在100%的治疗组仓鼠中观察到完全消退，而在对照组仓鼠中未观察到消退。在第12天，治疗组仓鼠的平均肿瘤体积约为对照组仓鼠的1/1000。在治疗组仓鼠中，完全消退后3个月内未观察到骨肉瘤复发。
这些结果表明该治疗方法对骨肉瘤有效。
