Georgiade G S, Georgiade N G, Grandy R P, Goldenheim P D
Department of Surgery, Duke University Medical Center, Durham, NC 27710.
Adv Ther. 1990 Jan-Feb;7(1):1-8.
One hundred fifty hospitalized patients undergoing elective surgery were enrolled in an open study designed to assess the bactericidal and clinical efficacy of a preoperative skin preparation procedure--application of 7.5% povidone-iodine surgical scrub followed by 10% povidone-iodine antiseptic solution. Of 99 patients with bacterial colonization of the skin prior to surgery, 84 patients (85%) had no detectable levels of bacteria at completion of surgery; bacterial flora persisted after surgery in the remaining 15 patients (15%). The difference between pre- and post-surgical bacterial colonization was statistically significant (p = 0.004). Clinically, none of the 146 patients evaluable for analysis of efficacy developed infections at the incision or suture site and there were no incidents of skin irritation at the surgical site during the postoperative observation period. Thus, preoperative cleansing with povidone-iodine surgical scrub followed by povidone-iodine antiseptic solution is an effective, non-irritating bactericidal regimen for use at surgical incision sites.
150名接受择期手术的住院患者参与了一项开放性研究，该研究旨在评估一种术前皮肤准备程序的杀菌效果和临床疗效，即先用7.5%聚维酮碘手术擦洗剂，再用10%聚维酮碘消毒液。在99名术前皮肤有细菌定植的患者中，84名患者（85%）在手术结束时细菌检测不到；其余15名患者（15%）术后细菌菌群持续存在。术前和术后细菌定植的差异具有统计学意义（p = 0.004）。临床上，146名可评估疗效的患者中，没有一人在切口或缝合部位发生感染，术后观察期内手术部位也没有皮肤刺激事件。因此，先用聚维酮碘手术擦洗剂，再用聚维酮碘消毒液进行术前清洁，是一种用于手术切口部位的有效、无刺激性的杀菌方案。
