人12型腺病毒温度敏感突变体转化能力的降低

Decreased transforming ability of a temperature-sensitive mutant of human adenovirus type 12.

作者信息

Hama S, Kimura G

出版信息

Cancer Lett. 1976 Sep;2(1):53-7. doi: 10.1016/s0304-3835(76)80011-0.

Abstract

A mutant of human adenovirus type 12, temperature-sensitive for virus replication an for the enhancement of thymidine incorporation in resting human embryonic kidney cells, is described. The mutant was also temperature-sensitive for transformation of rat cells. The results indicate that a viral gene required for the virus growth cycle is also required for transformation.

摘要

描述了一种人12型腺病毒突变体，其在病毒复制以及增强静止的人胚肾细胞中胸苷掺入方面对温度敏感。该突变体对大鼠细胞的转化也对温度敏感。结果表明，病毒生长周期所需的一种病毒基因对于转化也是必需的。