Amis A A, Kempson S A, Campbell J R, Miller J H
Biomechanics Section, Imperial College, London, England.
J Bone Joint Surg Br. 1988 Aug;70(4):628-34. doi: 10.1302/0301-620X.70B4.3403613.
The anterior cruciate ligament was replaced in rabbits, using implants of carbon or polyester filaments with known mechanical properties. The biocompatibility of the implants was assessed in detail using light microscopy, and scanning and transmission electron microscopy. Mechanical tests were made of stability, in comparison with normal joints and controls after excision of the ligament. Some carbon fibre implants broke down in vivo, allowing instability; the fragments caused chronic inflammation. Intact carbon implants did not induce the formation of neoligaments; they were covered by tissue, but there was no ingrowth. Polyester did not degrade mechanically and supported early collagenous ingrowth within the implant, even in the mid-joint space. It was concluded that there was no justification for the use of carbon fibres as anterior cruciate replacements; polyester appeared to be suitable.
使用具有已知机械性能的碳或聚酯丝植入物对兔的前交叉韧带进行置换。通过光学显微镜、扫描电子显微镜和透射电子显微镜详细评估植入物的生物相容性。与正常关节以及韧带切除后的对照组相比，对稳定性进行了力学测试。一些碳纤维植入物在体内分解，导致不稳定；碎片引起慢性炎症。完整的碳植入物未诱导新韧带形成；它们被组织覆盖，但没有向内生长。聚酯在力学上不会降解，并支持植入物内早期的胶原向内生长，即使在关节中部空间也是如此。得出的结论是，使用碳纤维作为前交叉韧带替代物没有依据；聚酯似乎是合适的。
