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呼吸力学功能常见指标的生理基础及解读

Physiologic basis and interpretation of common indices of respiratory mechanical function.

作者信息

Drazen J M

出版信息

Environ Health Perspect. 1976 Aug;16:11-6. doi: 10.1289/ehp.761611.

Abstract

Tests of pulmonary mechanical function may be used in determining the prominent site of pulmonary reaction to intervention. Responses may be localized from a knowledge of changes in lung resistance and compliance. A peripheral airway or parenchymal response is characterized by a decrease in lung compliance. A central airway reaction is characterized by an increase in pulmonary resistance. In mixed reactions both parameters may change. In this communication some of the physiologic determinants of pulmonary resistance and compliance are discussed and examples of localized responses given.

摘要

肺功能测试可用于确定肺部对干预措施反应的主要部位。根据肺阻力和顺应性的变化情况,可判断反应的部位。外周气道或实质反应的特征是肺顺应性降低。中央气道反应的特征是肺阻力增加。在混合反应中,两个参数可能都会改变。在本交流中,将讨论肺阻力和顺应性的一些生理决定因素,并给出局部反应的示例。

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本文引用的文献

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Mechanics of respiration in unanesthetized guinea pigs.未麻醉豚鼠的呼吸力学
Am J Physiol. 1958 Feb;192(2):364-8. doi: 10.1152/ajplegacy.1958.192.2.364.
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Mechanical factors in distribution of pulmonary ventilation.肺通气分布中的机械因素。
J Appl Physiol. 1956 Jan;8(4):427-43. doi: 10.1152/jappl.1956.8.4.427.
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Mechanism of compliance change in excised rat lungs at low transpulmonary pressure.
J Appl Physiol. 1970 Dec;29(6):780-5. doi: 10.1152/jappl.1970.29.6.780.
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In vivo visualization of small-airway constriction after pulmonary microembolism in cats and dogs.
J Appl Physiol. 1970 Nov;29(5):646-50. doi: 10.1152/jappl.1970.29.5.646.
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Pulmonary physiologic abnormalities in experimental asthma in dogs.犬实验性哮喘中的肺生理异常
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