Chouza C, Romero S, Gomensoro J B
Neurol Neurocir Psiquiatr. 1976;17(4):255-68.
In 28% of patients treated for a long time with L-dopa, alone or combined with a decarboxilase inhibitor, the following "long-term syndrome" was observed: decrease in effectiveness, psychic disorders, intense abnormal movements, distonic attitudes, speech and gait disorders, orthostatic hypotension and/or general reprecussion. In 11% of the patients the "on-off" effect was studied (brisk alteranting Parkinsonic and improved states). Clinical observation during 14 hours a day was repeated with different dosages and different regimes of the drug; these modified the daily variations but did not eliminate the syndrome. The electromyographic studies also revealed the "on and off" phenomenon in different patients. When the "long-term syndrome" is severe, at times it is necessary to stop the drug; the secondary effects are thus decreased and, when the medication is given again, the therapeutic effectiveness is temporarily restored. When the drug is stopped the patients should be watched, since a "withdrawal syndrome" may appear.
在单独使用左旋多巴或与脱羧酶抑制剂联合长期治疗的患者中，有28%出现了以下“长期综合征”：疗效降低、精神障碍、剧烈异常运动、张力障碍姿势、言语和步态障碍、体位性低血压和/或全身反应。在11%的患者中研究了“开-关”效应（帕金森状态与改善状态的快速交替）。每天14小时的临床观察在不同剂量和不同用药方案下重复进行；这些改变了每日变化，但并未消除该综合征。肌电图研究也在不同患者中揭示了“开和关”现象。当“长期综合征”严重时，有时有必要停药；这样副作用会减少，再次给药时，治疗效果会暂时恢复。停药时应密切观察患者，因为可能会出现“戒断综合征”。
